Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

Autor: Pilar María Luque-Navarro, Elena Mariotto, Marco Ballarotto, Gianluca Rubbini, Francisco José Aguilar-Troyano, Alberto Fasiolo, Archimede Torretta, Emilio Parisini, Antonio Macchiarulo, Alejandro Laso, Carmen Marco, Giampietro Viola, María Paz Carrasco-Jimenez, Luisa Carlota López-Cara

Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 715 (2022)

Due to its role in lipid biosynthesis, choline kinase α1 (CKα1) is an interesting target for the development of new antitumor agents. In this work, we present a series of 41 compounds designed based on the well-known and successful strategy of intr

Externí odkaz: https://doaj.org/article/122063277df142bd9892a85aa125ed4d

Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

Autor: Eva Lhuissier, Céline Bazille, Juliette Aury-Landas, Nicolas Girard, Julien Pontin, Martine Boittin, Karim Boumediene, Catherine Baugé

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)

Abstract Background Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from that of three-dimensional (3D) o

Externí odkaz: https://doaj.org/article/18c8081c441749be9cd71f5e68702204

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Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats

Autor: Cecília Maria de Carvalho Xavier Holanda, Elias Herculano de Oliveira, Louisianny Guerra da Rocha, Vanessa Santos de Arruda Barbosa, Maria Helena Constantino Spyrides, Cícero Flávio Soares Aragão, Aldo da Cunha Medeiros

Publikováno v: Brazilian Archives of Biology and Technology, Vol 51, Iss spe, Pp 191-196 (2008)

The evidence that natural or synthetic drugs can affect the biodistribution of radiopharmaceuticals (radiobiocomplexes) in setting of nuclear medicine clinic is already known. We studied the effect of Paclitaxel, an anti-neoplastic agent for the trea

Externí odkaz: https://doaj.org/article/2d5c582e4ce444b4ba65427fd5b6800b

Zebrafish as a model organism for the study of toxicity and effectiveness of new antitumor therapies

Autor: Gutiérrez Lovera, Carlha Rodmar

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)

The zebrafish have many advantages that led to be a model organism with a great potential in translational research. The zebrafish embryos are an ideal platform to evaluate novel cancer therapies. For this reason, the main goal of this thesis has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::71a4a881ef576333983d0eb88802dc85
http://hdl.handle.net/10347/23184