Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Antituberculosis agent"'
Autor:
Rodney Dawson, Andreas H. Diacon, Simbarashe Takuva, Yongge Liu, Bo Zheng, Vatsala Karwe, Jeffrey Hafkin
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Delamanid and bedaquiline are two of the most recently developed antituberculosis (TB) drugs that have been extensively studied in patients with multidrug-resistant TB. There is currently a need for more potent, less-toxic drugs w
Externí odkaz:
https://doaj.org/article/e09144f4018641fda1b5b86c2867dd4b
Akademický článek
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Publikováno v:
Doklady Biochemistry and Biophysics. 499:266-272
The present study investigated Boerhaavia diffusa extract against Mycobacterium tuberculosis H37Rv (M.tb) infection in vitro and explored the underlying mechanism. The study demonstrated that Boerhaavia diffusa extract significantly (p0.05) reduced R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71de21e11761113f89bcca190ae4654c
https://doi.org/10.1134/s160767292104013x
https://doi.org/10.1134/s160767292104013x
Publikováno v:
Research Journal of Pharmacy and Technology. :3253-3261
Tuberculosis (TB) is an infectious disease caused by M. tuberculosis. A new series of four benzylformamide with chloro substitution were synthesized by multicomponent reaction method and screened for antituberculosis activity against Mycobacterium tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf432fd192426903afad599ed63023c
https://doi.org/10.52711/0974-360x.2021.00566
https://doi.org/10.52711/0974-360x.2021.00566
Akademický článek
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Autor:
Takumi Watanabe
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:620-631
Natural products are still rich sources of clinically used medicines and lead compounds for them. This review summarizes chemical studies carried out by the author on natural products of microorganism origin, many of which were discovered at the Inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671abe03410878d1fcaaf48ccee96275
https://doi.org/10.1248/cpb.c19-00215
https://doi.org/10.1248/cpb.c19-00215
Publikováno v:
Synthetic Communications. 49:1277-1285
A series of substituted 2-amino-1,3-thiazines were synthesized as amides (9a-9i), carbamates (9j-9m), sulfonamides (9n-9o) and urea derivatives (9p-9q) by treating the compound 7 with acid chloride...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4c1ebae8b19fca198ff37cfa84de48
https://doi.org/10.1080/00397911.2019.1597125
https://doi.org/10.1080/00397911.2019.1597125
Autor:
Motohiro Itotani, Makoto Matsumoto, Izuru Nakamura, Ohba Yoshio, Toshio Shinohara, Yohei Hayashi, Norimitsu Hariguchi, Shunpei Ishikawa, Miki Matsuba, Yoshikazu Kawano, Yoshikazu Haraguchi, Yukitaka Uematsu, Xiuhao Chen, Mamoru Fujiwara, Ryuki Kitamoto, Hiroshi Shimizu, Isao Takemura
Publikováno v:
Antimicrobial Agents and Chemotherapy
There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3,4-dihydroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40caed769eea3a26ef9d04c0b3a96237
https://doi.org/10.1128/aac.02020-19
https://doi.org/10.1128/aac.02020-19
Autor:
Helmuth Reuter, Andreas H. Diacon, Ahmed A. Abulfathi, Kim T. Adams, Elin M. Svensson, Peter R. Donald
Publikováno v:
British Journal of Clinical Pharmacology, 86, 11, pp. 2123-2132
Br J Clin Pharmacol
British Journal of Clinical Pharmacology, 86, 2123-2132
Br J Clin Pharmacol
British Journal of Clinical Pharmacology, 86, 2123-2132
Contains fulltext : 229215.pdf (Publisher’s version ) (Closed access) Following its introduction as an antituberculosis agent close to 75 years ago, the use of para-aminosalicylic acid (PAS) has been limited by gastrointestinal intolerance and mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a1681513bbf42fde74521efd9865aa
https://hdl.handle.net/2066/229215
https://hdl.handle.net/2066/229215
Publikováno v:
The Journal of Organic Chemistry. 83:10602-10612
The transition-metal-free synthesis of unsymmetrical and highly functionalized triarylmethanes through arylation of the situ generated o-QMs from diarylmethyl p-tolyl sulfones with aryl zinc reagents is described. Alkyl zinc reagents are also well to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89df392c54f37149558a5232d594875
https://doi.org/10.1021/acs.joc.8b01428
https://doi.org/10.1021/acs.joc.8b01428