Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

Autor: Luciana Morita Katiki, Leticia Norma Carpentieri Rodrigues, Beatriz Tavares Ferreira, Adriana Karla Cardoso Amorim Reis, Anna Carollina Moraes Tavares

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 55, Article number: e17776, Published: 25 NOV 2019
Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019)
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17776
Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17776
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodext

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