Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases A Phase 2 Randomized Clinical Trial

Autor: Arjen J. Witkamp, Joost Nederend, Andreas J A Bremers, Philip R. de Reuver, Wilhelmina M U van Grevenstein, Henk M.W. Verheul, Koen P. Rovers, Max J. Lahaye, Niels F. M. Kok, Jurriaan B. Tuynman, Checca Bakkers, Maartje Los, Ignace H. J. T. de Hingh, Anna M.J. Thijs, Patrick H. J. Hemmer, Alexandra R. M. Brandt-Kerkhof, Miriam Koopman, Onno Kranenburg, Petur Snaebjornsson, Marcel G. W. Dijkgraaf, Simon W. Nienhuijs, Arend G. J. Aalbers, Schelto Kruijff, Jacobus W. A. Burger, Tineke E. Buffart, Derk Jan A. de Groot, Esther van Meerten, Iris van 't Erve, Geert-Jan Creemers, Miranda Kusters, Pieter J. Tanis, Eva V. E. Madsen, Remond J.A. Fijneman, Kathelijn S. Versteeg, Djamila Boerma, Cornelis J A Punt, Marinus J. Wiezer

Publikováno v: Rovers, K P, Bakkers, C, Nienhuijs, S W, Burger, J W A, Creemers, G-J M, Thijs, A M J, Brandt-Kerkhof, A R M, Madsen, E V E, van Meerten, E, Tuynman, J B, Kusters, M, Versteeg, K S, Aalbers, A G J, Kok, N F M, Buffart, T E, Wiezer, M J, Boerma, D, Los, M, de Reuver, P R, Bremers, A J A, Verheul, H M W, Kruijff, S, de Groot, D J A, Witkamp, A J, van Grevenstein, W M U, Koopman, M, Nederend, J, Lahaye, M J, Kranenburg, O, Fijneman, R J A, van 't Erve, I, Snaebjornsson, P, Hemmer, P H J, Dijkgraaf, M G W, Punt, C J A, Tanis, P J & de Hingh, I H J T 2021, ' Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases: A phase 2 randomized clinical trial ', JAMA Surgery, vol. 156, no. 8, pp. 710-720 . https://doi.org/10.1001/jamasurg.2021.1642
JAMA Surgery, 156(8), 710-720. American Medical Association
JAMA surgery, 156(8), 710-720. American Medical Association
JAMA Surgery, 156(8), 710-720. AMER MEDICAL ASSOC
JAMA Surgery, 156, 710-720
JAMA Surg
JAMA Surgery, 156, 8, pp. 710-720

Contains fulltext : 238268.pdf (Publisher’s version ) (Closed access) IMPORTANCE: To date, no randomized clinical trials have investigated perioperative systemic therapy relative to cytoreductive surgery and hyperthermic intraperitoneal chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375b682e7bd1c0c6ebfa96df3e48e33e
https://hdl.handle.net/11370/c9e531bb-9f62-460d-afc2-636baf20eec6

Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): a randomised, open-label phase 2/3 trial

Autor: M. Gershenson, David, Miller, Austin, E Brady, William, Paul, James, Carty, Karen, Rodgers, William, Millan, David, L Coleman, Robert, N Moore, Kathleen, Banerjee, Susana, Connolly, Kate, Alvarez Secord, Angeles, M O'Malley, David, Dorigo, Oliver, Gaillard, Stephanie, Gabra, Hani, Slomovitz, Brian, Hanjani, Parviz, Farley, John, Churchman, Michael, Ewing, Ailith, Hollis, Robb, Herrington, C Simon, Q Huang, Helen, B Wenzel, Lari, Gourley, Charlie

Publikováno v: M. Gershenson, D, Miller, A, E Brady, W, Paul, J, Carty, K, Rodgers, W, Millan, D, L Coleman, R, N Moore, K, Banerjee, S, Connolly, K, Alvarez Secord, A, M O'Malley, D, Dorigo, O, Gaillard, S, Gabra, H, Slomovitz, B, Hanjani, P, Farley, J, Churchman, M, Ewing, A, Hollis, R, Herrington, C S, Q Huang, H, B Wenzel, L & Gourley, C 2022, ' Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): a randomised, open-label phase 2/3 trial ', The Lancet, vol. 399, no. 10324, pp. 541-553 . https://doi.org/10.1016/S0140-6736(21)02175-9

BACKGROUND: Low-grade serous carcinoma of the ovary or peritoneum is characterised by MAPK pathway aberrations and its reduced sensitivity to chemotherapy relative to high-grade serous carcinoma. We compared the MEK inhibitor trametinib to physician'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::10daf3830e8817199b8469c4d2ece72c
https://hdl.handle.net/20.500.11820/745251c7-7e6d-4cf1-9129-3a76f1637764

Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma

Autor: Pieter Sonneveld, Meletios A. Dimopoulos, Meral Beksac, Bronno van der Holt, Sara Aquino, Heinz Ludwig, Sonja Zweegman, Thilo Zander, Elena Zamagni, Ruth Wester, Roman Hajek, Lucia Pantani, Luca Dozza, Francesca Gay, AnneMaria Cafro, Luca De Rosa, Annamaria Morelli, Henrik Gregersen, Nina Gulbrandsen, Petra Cornelisse, Rosella Troia, Stefania Oliva, Vincent van de Velden, KaLung Wu, Paula F. Ypma, Gerard Bos, Mark-David Levin, Luca Pour, Christoph Driessen, Annemiek Broijl, Alexandra Croockewit, Monique C. Minnema, Anders Waage, Cecilie Hveding, Niels W. C. J. van de Donk, Massimo Offidani, Giuseppe A. Palumbo, Andrew Spencer, Mario Boccadoro, Michele Cavo

Publikováno v: Sonneveld, P, Dimopoulos, M A, Beksac, M, van der Holt, B, Aquino, S, Ludwig, H, Zweegman, S, Zander, T, Zamagni, E, Wester, R, Hajek, R, Pantani, L, Dozza, L, Gay, F, Cafro, A M, De Rosa, L, Morelli, A, Gregersen, H, Gulbrandsen, N, Cornelisse, P, Troia, R, Oliva, S, van de Velden, V, Wu, K L, Ypma, P F, Bos, G, Levin, M D, Pour, L, Driessen, C, Broijl, A, Croockewit, A, Minnema, M C, Waage, A, Hveding, C, van de Donk, N W C J, Offidani, M, Palumbo, G A, Spencer, A, Boccadoro, M & Cavo, M 2021, ' Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 39, no. 32, pp. 3613-3622 . https://doi.org/10.1200/JCO.21.01045
Journal of Clinical Oncology, 39, 32, pp. 3613-3622
Journal of Clinical Oncology, 39, 3613-3622
Journal of Clinical Oncology, 39(32), 3613-3622. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(32), 3613-3622. American Society of Clinical Oncology
Sonneveld, P, Dimopoulos, M A, Beksac, M, van der Holt, B, Aquino, S, Ludwig, H, Zweegman, S, Zander, T, Zamagni, E, Wester, R, Hajek, R, Pantani, L, Dozza, L, Gay, F, Cafro, A, De Rosa, L, Morelli, A, Gregersen, H, Gulbrandsen, N, Cornelisse, P, Troia, R, Oliva, S, van de Velden, V, Wu, K, Ypma, P F, Bos, G, Levin, M-D, Pour, L, Driessen, C, Broijl, A, Croockewit, A, Minnema, M C, Waage, A, Hveding, C, van de Donk, N W C J, Offidani, M, Palumbo, G A, Spencer, A, Boccadoro, M & Cavo, M 2021, ' Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma ', Journal of Clinical Oncology, vol. 39, no. 32, JCO2101045, pp. 3613-3622 . https://doi.org/10.1200/JCO.21.01045

PURPOSE To address the role of consolidation treatment for newly diagnosed, transplant eligible patients with multiple myeloma in a controlled clinical trial. PATIENTS AND METHODS The EMN02/HOVON95 trial compared consolidation treatment with two cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d062212186695d034b375b07fa82bfad
https://research.vumc.nl/en/publications/2b32098e-ca08-476c-9883-09664c6f97bc

Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma

Autor: Enrique M. Ocio, Angelo Michele Carella, Maria-Victoria Mateos, Argiris Symeonidis, Heather Oakervee, Raymond H. Banh, Chang-Ki Min, Roman Hájek, Richard Greil, Pieter Sonneveld, Shang-Yi Huang, Carmen Kahatt, Ivan Spicka, Nathalie Meuleman, Sonia Extremera, James D'Rozario, Paul Cannell, Sara Martinez, Meletios A. Dimopoulos, Heinz Ludwig, Vicente Alfaro

Publikováno v: Annals of Hematology
Annals of Hematology, 98(9), 2139-2150. Springer-Verlag
Annals of hematology
Annals of hematology, 98 (9

The randomized phase III ADMYRE trial evaluated plitidepsin plus dexamethasone (DXM) versus DXM alone in patients with relapsed/refractory multiple myeloma after at least three but not more than six prior regimens, including at least bortezomib and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca21caae1db2c673a339baafea4841c
https://doi.org/10.1007/s00277-019-03739-2

Choosing the right strategy based on individualized treatment effect predictions: combination versus sequential chemotherapy in patients with metastatic colorectal cancer

Autor: C.J.A. Punt, Matthew T. Seymour, R.C.M. van Kruijsdijk, Frank L.J. Visseren, S.G. Elias, Angela M. Meade, Johannes J.M. Kwakman, Miriam Koopman

Publikováno v: Acta Oncologica, 58(3), 326. Informa Healthcare
Acta Oncologica, 58(3), 326-333. Informa Healthcare

Background: Translating results from randomized trials to individual patients is challenging, since treatment effects may vary due to heterogeneous prognostic characteristics. We aimed to demonstrate model development for individualized treatment eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df89b015e8150bef91ac13576c30fed
https://doi.org/10.1080/0284186x.2018.1564840