Blockade of oncogenic NOTCH1 with the SERCA inhibitor CAD204520 in T cell acute lymphoblastic leukemia

Autor: Maike Bublitz, William Dalby-Brown, Franco Aversa, Paolo Sportoletti, Anne-Marie Lund Winther, Marilena Baglione, Giorgia Rastelli, Chiara Rompietti, Rocchina Vilella, Donatella Stilli, Caterina Loiacono, Federica Rizzi, Samuel Kitara, Luca Pagliaro, Giovanni Roti, Andrea Gherli, Claus Olesen, Anna Montanaro, Roberta La Starza, Monia Savi, Matteo Marchesini, Leonardo Bocchi, Cristina Mecucci, Laura Patrizi, Sabine Heit, Claudia Sorrentino, Jesper V. Møller, Kimberly Stegmaier

Publikováno v: Cell Chem Biol
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002

The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e63576c860546d9cf10c8571266edb
https://doi.org/10.1016/j.chembiol.2020.04.002

Work overload is related to increased risk of error during chemotherapy preparation

Autor: Sandrine Fleury, Christophe Combescure, Farshid Sadeghipour, Lucie Bouchoud, Pascal Bonnabry, Ludivine Falaschi, Laurent Carrez

Publikováno v: Journal of Oncology Pharmacy Practice, Vol. 25, No 6 (2019) pp. 1456-1466

PurposeChemotherapy preparation units face peaks in activity leading to high workloads and increased stress. The present study evaluated the impact of work overloads on the safety and accuracy of manual preparations.MethodSimulating overwork, operato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3dbb6d20dc0600e4115f89a26db308
https://pubmed.ncbi.nlm.nih.gov/31084249

Study of the combination of self-activating photodynamic therapy and chemotherapy for cancer treatment

Autor: Paulo J.O. Ferreira, Ara Núñez-Montenegro, Luís Pinto da Silva, Joaquim C.G. Esteves da Silva, Carla M. Magalhães, Diana Duarte, José E. Rodríguez-Borges, Nuno Vale

Publikováno v: Biomolecules
Biomolecules, Vol 9, Iss 8, p 384 (2019)
Volume 9
Issue 8

Cancer is a very challenging disease to treat, both in terms of treatment efficiency and side-effects. To overcome these problems, there have been extensive studies regarding the possibility of improving treatment by employing combination therapy, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a00e5b60cbfe2f218e0a49b922bc3f
https://hdl.handle.net/10216/136251

Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides

Autor: Ambre Dezaire, Sébastien Prévost, Alexandre E. Escargueil

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (8), pp.4871-4881. ⟨10.1021/acs.joc.8b00531⟩

International audience; An intramolecular aryne Diels-Alder reaction with a furan moiety was applied to the synthesis of dihydrobenzo[ de]isochromenes as intermediates toward naphthalimides. After oxidation, this method offers an efficient approach f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4412eb34dce664a9d33fc3634476a4
https://hal-polytechnique.archives-ouvertes.fr/hal-02091716

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Autor: Olivier Zava, Frédéric Schmitt, Padavattan Govindaswamy, Georg Süss-Fink, Lucienne Juillerat-Jeanneret, Bruno Therrien

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, vol. 14, no. 1, pp. 101-109

Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e1f65a2d32ce211e6691c9404e3cca
https://doi.org/10.1007/s00775-008-0427-y