Výsledky vyhledávání - "Antineoplastic/toxicity"

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Autor: da Silva Ferreira, A R, van der Aa, S A J, Wehkamp, T, Wardill, H R, Ten Klooster, J P, Garssen, J, Harthoorn, L F, Hartog, A, Harmsen, H J M, Tissing, W J E, van Bergenhenegouwen, J, Afd Pharmacology, Pharmacology

Publikováno v: Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports
Scientific Reports, 11:22911. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports

Background: Gastrointestinal mucositis remains a significant complication of anticancer treatment, with limited anti-mucositis interventions. Currently, there are few validated in vitro systems suitable to study the mechanisms of mucosal injury. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0be1bb49864df41a96eba18f87645
https://dspace.library.uu.nl/handle/1874/419704

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Assessment of acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes

Autor: Taina Palosaari, Jochem Louisse, Pilar Prieto, Francesca Pistollato, Rob C. I. Wüst, Susanne Bremer, Manuela Barilari, Peter Macko

Publikováno v: Toxicology in Vitro, 42, 182-190. Elsevier Limited
Louisse, J, Wüst, R C I, Pistollato, F, Palosaari, T, Barilari, M, Macko, P, Bremer, S & Prieto, P 2017, ' Assessment of acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes ', Toxicology in Vitro, vol. 42, pp. 182-190 . https://doi.org/10.1016/j.tiv.2017.04.023
Toxicology in vitro, 42, 182-190. Elsevier Limited

The present study assesses acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), with the aim to obtain in vitro biomarkers that can be used as readouts to predict in vivo cardiotoxicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12badb039aa75c4161220a991025aafc
http://www.scopus.com/inward/record.url?scp=85018349514&partnerID=8YFLogxK

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Dissertation/ Thesis

Toxicidade e ação antitumoral de um derivado do quimioterápico etoposídeo (oleato de etoposídeo) associado a uma microemulsão rica em colesterol

Autor: Prete, Ana Cristina Lo

Ao utilizar uma microemulsão lipídica artificial rica em colesterol (LDE), como transportador de fármacos antineoplásicos, é possível aumentar a dose administrada com redução dos efeitos tóxicos. Quando injetada na circulação, a LDE liga-s

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-24022015-073248/

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Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats

Autor: Gabriel O. Oludadepo, Kennedy I. Amagon, Abidemi J. Akindele, Daniel D. Osiagwu, Dhirendra Pratap Singh

Publikováno v: Pharmacology Research & Perspectives

This study investigated the protective effects of carvedilol alone and coadministered with prednisolone and diltiazem on doxorubicin (DOX) and 5‐fluorouracil (5‐FU)‐induced toxicity. Each of 2 pools of 70 female rats were randomly allotted into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4370acd2624ae1c0fa90674e3b9cbb76
https://doi.org/10.1002/prp2.381

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