In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Autor: Freitas Camila S., Lage Daniela P., Oliveira-da-Silva João A., Costa Rafaella R., Mendonça Débora V.C., Martins Vívian T., Reis Thiago A.R., Antinarelli Luciana M.R., Machado Amanda S., Tavares Grasiele S.V., Ramos Fernanda F., Brito Rory C.F., Ludolf Fernanda, Chávez-Fumagalli Miguel A., Roatt Bruno M., Ramos Gabriela S., Munkert Jennifer, Ottoni Flaviano M., Campana Priscilla R.V., Duarte Mariana C., Gonçalves Denise U., Coimbra Elaine S., Braga Fernão C., Pádua Rodrigo M., Coelho Eduardo A.F.

Publikováno v: Parasite, Vol 28, p 38 (2021)

Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileish

Externí odkaz: https://doaj.org/article/ab112e002ed04e84834f4985e03a8907

A chloroquinoline derivate presents effective in vitro and in vivo antileishmanial activity against Leishmania species that cause tegumentary and visceral leishmaniasis

Autor: Sousa, Jessica K.T., Antinarelli, Luciana M.R., Mendonça, Débora V.C., Lage, Daniela P., Tavares, Grasiele S.V., Dias, Daniel S., Ribeiro, Patrícia A.F., Ludolf, Fernanda, Coelho, Vinicio T.S., Oliveira-da-Silva, João A., Perin, Luísa, Oliveira, Bianka A., Alvarenga, Denis F., Chávez-Fumagalli, Miguel A., Brandão, Geraldo C., Nobre, Vandack, Pereira, Guilherme R., Coimbra, Elaine S., Coelho, Eduardo A.F.

Publikováno v: In Parasitology International December 2019 73

In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection

Autor: Mendonça, Débora V.C., Tavares, Grasiele S.V., Lage, Daniela P., Soyer, Tauane G., Carvalho, Lívia M., Dias, Daniel S., Ribeiro, Patrícia A.F., Ottoni, Flaviano M., Antinarelli, Luciana M.R., Vale, Danniele L., Ludolf, Fernanda, Duarte, Mariana C., Coimbra, Elaine S., Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Menezes-Souza, Daniel, Barichello, José Mário, Alves, Ricardo J., Coelho, Eduardo A.F.

Publikováno v: In Biomedicine & Pharmacotherapy January 2019 109:779-787

Quinoline derivatives: Synthesis, leishmanicidal activity and involvement of mitochondrial oxidative stress as mechanism of action.

Autor: Coimbra, Elaine S.¹ elaine.coimbra@ufjf.edu.br, Antinarelli, Luciana M.R.¹, Silva, Natália P.¹, Souza, Isabela O.², Meinel, Raissa S.², Rocha, Marcele N.³, Soares, Rodrigo P.P.³, da Silva, Adilson D.² david.silva@ufjf.edu.br

Publikováno v: Chemico-Biological Interactions. Dec2016, Vol. 260, p50-57. 8p.

Evaluation of the in vitro and in vivo antileishmanial activity of a chloroquinolin derivative against Leishmania species capable of causing tegumentary and visceral leishmaniasis.

Autor: Soyer, Tauane G.¹ (AUTHOR), Mendonça, Débora V.C.¹ (AUTHOR), Tavares, Grasiele S.V.¹ (AUTHOR), Lage, Daniela P.¹ (AUTHOR), Dias, Daniel S.¹ (AUTHOR), Ribeiro, Patrícia A.F.¹ (AUTHOR), Perin, Luisa¹ (AUTHOR), Ludolf, Fernanda¹ (AUTHOR), Coelho, Vinicio T.S.¹ (AUTHOR), Ferreira, Andreza C.G.² (AUTHOR), Neves, Pedro H.A.S.² (AUTHOR), Matos, Guilherme F.² (AUTHOR), Chávez-Fumagalli, Miguel A.¹ (AUTHOR), Coimbra, Elaine S.³ (AUTHOR), Pereira, Guilherme R.² (AUTHOR), Coelho, Eduardo A.F.^1,4 (AUTHOR) eduardoferrazcoelho@yahoo.com.br, Antinarelli, Luciana M.R.¹ (AUTHOR)

Publikováno v: Experimental Parasitology. Apr2019, Vol. 199, p30-37. 8p.