Microbiome-derived antimicrobial peptides offer therapeutic solutions for the treatment of Pseudomonas aeruginosa infections

Autor: Adam J. Mulkern, Linda B. Oyama, Alan R. Cookson, Christopher J. Creevey, Toby J. Wilkinson, Hamza Olleik, Marc Maresca, Giarla C. da Silva, Patricia P. Fontes, Denise M. S. Bazzolli, Hilario C. Mantovani, Bamu F. Damaris, Luis A. J. Mur, Sharon A. Huws

Publikováno v: npj Biofilms and Microbiomes
npj Biofilms and Microbiomes, 2022, 8, pp.70. ⟨10.1038/s41522-022-00332-w⟩
Mulkern, A J, Oyama, L B, Cookson, A R, Creevey, C J, Wilkinson, T J, Olleik, H, Maresca, M, da Silva, G C, Fontes, P P, Bazzolli, D M S, Mantovani, H C, Damaris, B F, Mur, L A J & Huws, S A 2022, ' Microbiome-derived antimicrobial peptides offer therapeutic solutions for the treatment of Pseudomonas aeruginosa infections ', NPJ biofilms and microbiomes, vol. 8, no. 1, 70 . https://doi.org/10.1038/s41522-022-00332-w
Mulkern, A J, Oyama, L B, Cookson, A R, Creevey, C J, Wilkinson, T J, Olleik, H, Maresca, M, da Silva, G C, Fontes, P P, Bazzolli, D M S, Mantovani, H C, Damaris, B F, Mur, L A J & Huws, S A 2022, ' Microbiome-derived antimicrobial peptides offer therapeutic solutions for the treatment of Pseudomonas aeruginosa infections ', NPJ Biofilms and Microbiomes, vol. 8, 70 . https://doi.org/10.1038/s41522-022-00332-w

Microbiomes are rife for biotechnological exploitation, particularly the rumen microbiome, due to their complexicity and diversity. In this study, antimicrobial peptides (AMPs) from the rumen microbiome (Lynronne 1, 2, 3 and P15s) were assessed for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e01a0f8b3d057f7b1e7f1c751098ff
https://doi.org/10.1038/s41522-022-00332-w

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Autor: Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e45c56c9b3fcde327e5251318035d4
https://escholarship.org/uc/item/0388t0qm

Specific surface glycan decorations enable antimicrobial peptide resistance in plant-beneficial pseudomonads with insect-pathogenic properties

Autor: Kupferschmied, P., Chai, T., Flury, P., Blom, J., Smits, T.H., Maurhofer, M., Keel, C.

Publikováno v: Environmental microbiology, vol. 18, no. 11, pp. 4265-4281

Some plant-beneficial pseudomonads can invade and kill pest insects in addition to their ability to protect plants from phytopathogens. We explored the genetic basis of O-polysaccharide (O-PS, O-antigen) biosynthesis in the representative insecticida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5f03686ec0f213e7fb137a3d6023a762
https://pubmed.ncbi.nlm.nih.gov/27727519

Nitric Oxide Release from Antimicrobial Peptide Hydrogels for Wound Healing

Autor: Cristina C. Barrias, Nuno Vale, Luís Gales, Joana Durão, Salome Gomes, Paula Gomes

Publikováno v: Biomolecules
Volume 9
Issue 1
Biomolecules, Vol 9, Iss 1, p 4 (2018)

Nitric oxide (NO) is an endogenously produced molecule that has been implicated in several wound healing mechanisms. Its topical delivery may improve healing in acute or chronic wounds. In this study an antimicrobial peptide was synthesized which sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edaccd50de7dc98614001eeeb8e9d0b
https://doi.org/10.3390/biom9010004

L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane

Autor: Sandra Sousa, Rita Pombinho, Filipe Carvalho, Richard Gallo, Gonçalo Covas, Sergio Raposo Filipe, Didier Cabanes, Giulia Gasparini, Magda Atilano

Publikováno v: PLoS pathogens, vol 11, iss 5
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Pathogens, Vol 11, Iss 5, p e1004919 (2015)
PLoS Pathogens

Listeria monocytogenes is an opportunistic Gram-positive bacterial pathogen responsible for listeriosis, a human foodborne disease. Its cell wall is densely decorated with wall teichoic acids (WTAs), a class of anionic glycopolymers that play key rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1951a493c7bc24c791c103221d9e29ce
https://hdl.handle.net/10216/114513