Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Autor: Tom Lund, Roberto Salgado, Rachel Rosenthal, Shan E Ahmed Raza, Marco Sereno, Sergio A. Quezada, Claire Rachel Smith, Selvaraju Veeriah, Leah Officer, Mariam Jamal-Hanjani, Nicholas McGranahan, David Moore, Yinyin Yuan, Maise Al Bakir, Allan Hackshaw, Crispin T. Hiley, Sherene Loi, Luis Zapata, John Le Quesne, Charles Swanton, Teresa Marafioti, Ayse Akarca, Khalid AbdulJabbar

Publikováno v: Nature Medicine
TRACERx Consortium & Blackhall, F 2020, ' Geospatial immune variability illuminates differential evolution of lung adenocarcinoma ', Nature Medicine, vol. 26, no. 7, pp. 1054-1062 . https://doi.org/10.1038/s41591-020-0900-x
Nat Med

Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells towards immune escape(1–5). However, the spatial configurations of immune and stromal cells, which may shed light on the evolution of immune e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe561e7f512e080872ad4e0b539a3011

AON-Mediated Exon Skipping to Bypass Protein Truncation in Retinal Dystrophies Due to the Recurrent CEP290 c.4723A > T Mutation. Fact or Fiction?

Autor: Imad Ghazi, Isabelle Perrault, Nicolas Goudin, Jean-Michel Rozet, Josseline Kaplan, Sabine Defoort-Dhellemmes, Iris Barny, Christel Michel, Xavier Gérard

Publikováno v: Genes, Vol 10, Iss 5, p 368 (2019)
Genes, vol. 10, no. 5

Mutations in CEP290 encoding a centrosomal protein important to cilia formation cause a spectrum of diseases, from isolated retinal dystrophies to multivisceral and sometimes embryo–lethal ciliopathies. In recent years, endogenous and/or selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d1b3289409a8e17d29649a47b30231
https://www.mdpi.com/2073-4425/10/5/368

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

Autor: Christina Dahl, Christer Lundell-Ek, Henrik J. Ditzel, Jann Mortensen, Karine N. Dzhandzhugazyan, Line Bille Madsen, Johnny Jon Fang, Helle Broholm, Walter Fischer, Morten F. Gjerstorff, Tim Lundby, Ian Law, Per Guldberg, Rikke Sick Andersen, Martin Roland Jensen, Alexei F. Kirkin, Aase Wagner

Publikováno v: Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, 785 . https://doi.org/10.1038/s41467-018-03217-9
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, no. 1, 785 . https://doi.org/10.1038/s41467-018-03217-9

In cancer cells, cancer/testis (CT) antigens become epigenetically derepressed through DNA demethylation and constitute attractive targets for cancer immunotherapy. Here we report that activated CD4+ T helper cells treated with a DNA-demethylating ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2073161fab54b049c7d89cd5b4119cc
https://doi.org/10.1038/s41467-018-03217-9

Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-βin Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis

Autor: Biserka Radošević-Stašić, Tanja Grubić-Kezele, Hrvoje Jakovac, Čedomila Milin, Gordana Blagojević Zagorac, Robert Domitrović

Publikováno v: Clinical and Developmental Immunology
Volume 213
es http://dx.doi.org/10.1155/2013/750406
Clinical & developmental immunology
Volume 2013
Clinical and Developmental Immunology, Vol 2013 (2013)

In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aba5e17e3d703208e83d4141184f317
https://doi.org/10.1155/2013/750406

Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study

Autor: Tsun Leung Chan, Eugène T P Verwiel, Irma Kluijt, Diana Eccles, Rolf H. Sijmons, Egbert J.W. Redeker, Rachel S. van der Post, Encarna B. Gomez Garcia, Reinhard Büttner, Cora M. Aalfs, Roland P. Kuiper, Johan J.P. Gille, Bernadette P M van Nesselrooij, Frans B. L. Hogervorst, Marjolijn J L Ligtenberg, Tracy Graham, Julie O. Culver, Edith Olah, Monique Goossens, Carli M. J. Tops, Elke Holinski-Feder, David J. Bunyan, Marielle E. van Gijn, Frederik J. Hes, Suet Yi Leung, Pierre O. Chappuis, Monika Morak, Edward M Leter, Nils Rahner, Lea Velsher, János Papp, Renee C. Niessen, J. Han van Krieken, Lambertus A. Kiemeney, Ad Geurts van Kessel, Charlotte W. Ockeloen, Nicoline Hoogerbrugge, Marlies Kempers, Iris D. Nagtegaal, Verena Steinke, Hans K. Schackert, Matthias Kloor, Melanie R. Palomares, Sapna Syngal, Pierre Hutter, Elena M. Stoffel

Publikováno v: Kempers, M J E, Kuiper, R P, Ockeloen, C W, Chappuis, P O, Hutter, P, Rahner, N, Schackert, H K, Steinke, V, Holinski-Feder, E, Morak, M, Kloor, M, Buttner, R, Verwiel, E T P, van Krieken, J H, Nagtegaal, I D, Goossens, M, van der Post, R S, Niessen, R C, Sijmons, RH, Kluijt, I, Hogervorst, F B L, Leter, E M, Gille, J J P, Aalfs, C M, Redeker, E J W, Hes, F J, Tops, C M J, van Nesselrooij, B P M, van Gijn, M E, Garcia, E B G, Eccles, D M, Bunyan, D J, Syngal, S, Stoffel, E M, Culver, J O, Palomares, M R, Graham, T, Velsher, L, Papp, J, Olah, E, Chan, T L, Leung, S Y, van Kessel, A G, Kiemeney, L A L M, Hoogerbrugge, N & Ligtenberg, M J L 2011, ' Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study ', Lancet Oncology, vol. 12, no. 1, pp. 49-55 . https://doi.org/10.1016/S1470-2045(10)70265-5
The Lancet Oncology, 49-55
STARTPAGE=49;ENDPAGE=55;TITLE=The Lancet Oncology
Lancet Oncology, 12, 1, pp. 49-55
Lancet oncology, 12(1), 49-55. Elsevier Science
Lancet Oncology, 12, 49-55
lancet oncology, 12(1), 49-55. Lancet Publishing Group
Lancet Oncology, 12(1), 49-55. ELSEVIER SCIENCE INC
Lancet Oncology, 12(1), 49-55. Lancet Publishing Group

Summary Background Lynch syndrome is caused by germline mutations in MSH2, MLH1, MSH6 , and PMS2 mismatch-repair genes and leads to a high risk of colorectal and endometrial cancer. We previously showed that constitutional 3′ end deletions of EPCAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f4a39c0f97e31d38f52cdcda56a8a1
https://hdl.handle.net/2066/97324