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pro vyhledávání: '"Antigens, Neoplasm/chemistry/immunology/therapeutic use"'
Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy
Autor:
Pierre-Yves Dietrich, Harpreet Singh-Jasuja, Jens Fritsche, Steffen Walter, Norbert Hilf, Judith Bucher, Katharina Dorsch, Christel Herold-Mende, Jennifer Lohr, Sylvia Flohr, Peter Lewandrowski, Stefan Stevanovic, Verona Vass, Paul R. Walker, Claudia Trautwein, Philipp Beckhove, Valérie Dutoit, Oliver Schoor, Toni Weinschenk, Hans-Georg Rammensee
Publikováno v:
Brain, Vol. 135, No Pt 4 (2012) pp. 1042-54
Peptides presented at the cell surface reflect the protein content of the cell; those on HLA class I molecules comprise the critical peptidome elements interacting with CD8 T lymphocytes. We hypothesize that peptidomes from ex vivo tumour samples enc