Megakaryocyte lineage development is controlled by modulation of protein acetylation

Autor: Bartels, Marije, Govers, Anita, Polak, Roel, Vervoort, Stephin, van Boxtel, Ruben, Pals, Cornelieke, Bierings, Marc, van Solinge, Wouter, Egberts, Toine, Nieuwenhuis, Edward, Mokry, Michal, Coffer, Paul James, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: PLoS ONE, 13(4). Public Library of Science
PLoS One, 13(4). Public Library of Science
PLoS ONE, Vol 13, Iss 4, p e0196400 (2018)
PLoS One (online), 13(4):e0196400. Public Library of Science
PLoS ONE

Treatment with lysine deacetylase inhibitors (KDACi) for haematological malignancies, is accompanied by haematological side effects including thrombocytopenia, suggesting that modulation of protein acetylation affects normal myeloid development, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ae689d101bc30f4d2b578bc0bfe331
https://dspace.library.uu.nl/handle/1874/365150

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Autor: K Kollmann, W Warsch, C Gonzalez-Arias, F L Nice, E Avezov, J Milburn, J Li, D Dimitropoulou, S Biddie, M Wang, E Poynton, M Colzani, M R Tijssen, S Anand, U McDermott, B Huntly, T Green

Publikováno v: Kollmann, K, Warsch, W, Gonzalez-Arias, C, Nice, F L, Avezov, E, Milburn, J, Li, J, Dimitropoulou, D, Biddie, S, Wang, M, Poynton, E, Colzani, M, Tijssen, M R, Anand, S, McDermott, U, Huntly, B & Green, T 2017, ' A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation ', Leukemia, vol. 31, no. 4, pp. 934-944 . https://doi.org/10.1038/leu.2016.280
Leukemia

Most myeloproliferative neoplasm (MPN) patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64fc6363344fd1a5c016cf0ddbaeb804
https://www.repository.cam.ac.uk/handle/1810/261276

Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury

Autor: Ali Koçyiğit, Sebahat Turgut, Melek Tunc Ata, Günfer Turgut, Metin Akbulut, Aysun Karabulut, Hande Senol

Objective To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI). Methods Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984d88bce856121cdbda9d1bbb1d6ee2

Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: A randomized trial

Autor: Emiliano Giostra, Antoine Hadengue, Yves Chalandon, Laurent Spahr, Laura Rubbia-Brandt, Jean-Francois Lambert, Jean-Louis Frossard

Publikováno v: Hepatology, Vol. 48, No 1 (2008) pp. 221-9

Liver failure is the major cause of death in alcoholic steatohepatitis (ASH). In experimental hepatitis, granulocyte-colony stimulating factor (G-CSF) mobilizes hematopoietic stem cells, induces liver regeneration, and improves survival. We studied t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a22fc4390205df46d85b5e4e8c362a
https://doi.org/10.1002/hep.22317

Bone marrow stromal proteoglycans regulate megakaryocytic differentiation of human progenitor cells

Autor: Tanja Netelenbos, Floortje L. Kessler, Peter C. Huijgens, Jeroen Janssen, Angelika M. Dräger, Jakob Van Den Born, Sonja Zweegman, Adriana M.C. Mus

Publikováno v: Experimental Cell Research, 299(2), 383-392. HANLEY & BELFUS-ELSEVIER INC
Zweegman, S, Van Den Born, J, Mus, A M C, Kessler, F L, Janssen, J J W M, Netelenbos, T, Huijgens, P C & Dräger, A M 2004, ' Bone marrow stromal proteoglycans regulate megakaryocytic differentiation of human progenitor cells ', Experimental Cell Research, vol. 299, no. 2, pp. 383-392 . https://doi.org/10.1016/j.yexcr.2004.06.018
Experimental Cell Research, 299(2), 383-392. Academic Press Inc.

Adherence of hematopoietic progenitor cells (HPCs) to stroma is an important regulatory step in megakaryocytic differentiation. However, the mechanisms through which megakaryocytic progenitors are inhibited by stroma are poorly understood. We examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adef9571e27555b2a0b8418e6bc3929c
https://hdl.handle.net/1871/25972