Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Autor: Sharon R Lewin, Rachel D. Pascoe, Rémi Fromentin, Paul U. Cameron, Ashanti Dantanarayana, Celine Gubser, Thomas A Rasmussen, Lydie Trautman, Ajantha Solomon, Christopher Chiu, Vanessa A. Evans, James H McMahon, Judy Chang, Nicolas Chomont

Publikováno v: Chiu, C Y, Chang, J J, Dantanarayana, A I, Solomon, A, Evans, V A, Pascoe, R, Gubser, C, Trautman, L, Fromentin, R, Chomont, N, McMahon, J H, Cameron, P U, Rasmussen, T A & Lewin, S R 2022, ' Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy ', Journal of Immunology, vol. 208, no. 1, pp. 54-62 . https://doi.org/10.4049/jimmunol.2100367
J Immunol

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune checkpoint (IC) proteins on total and HIV-specific T-cells. Reversing immune exhaustion is one strategy to enhance the elim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bbff23e6545b23bc265b80b828ee9c
https://pure.au.dk/portal/da/publications/combination-immune-checkpoint-blockade-enhances-il2-and-cd107a-production-from-hivspecific-t-cells-ex-vivo-in-people-living-with-hiv-on-antiretroviral-therapy(b1e04674-c9d9-4b2c-85ec-4cc0210d139f).html

Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy

Autor: Dumauthioz, N., Labiano, S., Romero, P.

Publikováno v: Frontiers in immunology, vol. 9, pp. 2076

Tissue resident memory T cells (Trm) are a subset of memory T cells mainly described in inflammation and infection settings. Their location in peripheral tissues, such as lungs, gut, or skin, makes them the earliest T cell population to respond upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::8c82ee6b1fd1f5e256add27abb8b1986
https://serval.unil.ch/resource/serval:BIB_A1AD953828BB.P001/REF.pdf

Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis

Autor: H. O. Madsen, B. Kristensen, Terry J. Smith, Laszlo Hegedüs, Claus Henrik Nielsen

Publikováno v: Kristensen, B, Hegedüs, L, Smith, T J & Nielsen, C H 2015, ' Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis ', Clinical and Experimental Allergy, vol. 180, no. 1, pp. 58-69 . https://doi.org/10.1111/cei.12557

Summary T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa0b991c80d1942621ebd6c6eb84a6f
https://pubmed.ncbi.nlm.nih.gov/25412700

In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes

Autor: Daniel E. Speiser, Danila Valmori, Mikael J. Pittet, Pedro Romero, Jean-Charles Cerottini, Vincenzo Cerundolo, Donata Rimoldi, H R MacDonald, Danielle Liénard, Rod Dunbar

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 190, no. 6, pp. 775-782

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen–specific CD8+ T cells have so far not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5665ebffa3446a5c15e1f2ffb1c24b6f
http://europepmc.org/articles/PMC2195637

The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy

Autor: Pasero, C., Speiser, D.E., Derré, L., Olive, D.

Publikováno v: Current Opinion in Pharmacology, vol. 12, no. 4, pp. 478-485

The regulation of the immune system is controlled by many cell surface receptors. A prominent representative is the 'molecular switch' HVEM (herpes virus entry mediator) that can activate either proinflammatory or inhibitory signaling pathways. HVEM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::1a91a0c4cd4ef74660e4a7c03b78808b
https://serval.unil.ch/resource/serval:BIB_673AC528840D.P001/REF.pdf