Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Antigen escape"'
Autor:
Elżbieta Bartoszewska, Maciej Tota, Monika Kisielewska, Izabela Skowron, Kamil Sebastianka, Oliwia Stefaniak, Klaudia Molik, Jakub Rubin, Karolina Kraska, Anna Choromańska
Publikováno v:
Cells, Vol 13, Iss 18, p 1596 (2024)
Leukemia is a prevalent pediatric cancer with significant challenges, particularly in relapsed or refractory cases. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a personalized cancer treatment, modifying patients’ T cells to targ
Externí odkaz:
https://doaj.org/article/b256e547e1084f96962743432fc0c8b7
Autor:
Ruth Rodríguez-Pastor, Adam Z. Hasik, Nadav Knossow, Enav Bar-Shira, Naama Shahar, Ricardo Gutiérrez, Luis Zaman, Shimon Harrus, Richard E. Lenski, Jeffrey E. Barrick, Hadas Hawlena
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-15 (2023)
Abstract Background Pathogens face strong selection from host immune responses, yet many host populations support pervasive pathogen populations. We investigated this puzzle in a model system of Bartonella and rodents from Israel’s northwestern Neg
Externí odkaz:
https://doaj.org/article/4ab9bead19c345c6a5340102603b8ca3
Autor:
Norris Lam, Richard Finney, Shicheng Yang, Stephanie Choi, Xiaolin Wu, Lauren Cutmore, Jorge Andrade, Lei Huang, Christina Amatya, Margaret Cam, James N. Kochenderfer
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 132-149 (2023)
To address CD19 loss from lymphoma after anti-CD19 chimeric antigen receptor (CAR) T cell therapy, we designed a bicistronic construct encoding an anti-CD19 CAR and an anti-CD20 CAR. We detected deletions from the expected bicistronic construct seque
Externí odkaz:
https://doaj.org/article/8394a243d09d4dd3a0e473ce7dff27d0
Autor:
Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh, Ajaz A. Bhat
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-36 (2023)
Abstract Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells
Externí odkaz:
https://doaj.org/article/849387ccca01487e82e56bc5e5cb5949
Autor:
Dennis Christoph Harrer, Sin-Syue Li, Marcell Kaljanac, Markus Barden, Hong Pan, Hinrich Abken
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chimeric antigen receptor (CAR) T cells are “living drugs” that specifically recognize their target antigen through an antibody-derived binding domain resulting in T cell activation, expansion, and destruction of cognate target cells. The FDA/EMA
Externí odkaz:
https://doaj.org/article/2d292fc5486b4ce9af50e2613937e877
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Over the last decade, the survival outcome of patients with multiple myeloma (MM) has been substantially improved with the emergence of novel therapeutic agents, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies,
Externí odkaz:
https://doaj.org/article/7765787383f9469ba055b968775174cf
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Michael E. Barish, Lihong Weng, Dina Awabdeh, Yubo Zhai, Renate Starr, Massimo D'Apuzzo, Russell C. Rockne, Haiqing Li, Behnam Badie, Stephen J. Forman, Christine E. Brown
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 30, Iss , Pp 100801- (2022)
High-grade (WHO grades III-IV) glioma remains one of the most lethal human cancers. Adoptive transfer of tumor-targeting chimeric antigen receptor (CAR)-redirected T cells for high-grade glioma has revealed promising indications of anti-tumor activit
Externí odkaz:
https://doaj.org/article/56120e51ba104a24ab35eb76e9dec053
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer treatment, and it has achieved unprecedented success in hematological malignancies, especially in relapsed/refractory (R/R) B cell malignancies. At present, CD
Externí odkaz:
https://doaj.org/article/c4fd890d0a4d4e6c8378538d2d224213