Zobrazeno 1 - 10
of 3 384
pro vyhledávání: '"Antigen binding"'
Autor:
Alessia Ametrano, Bruno Miranda, Rosalba Moretta, Principia Dardano, Luca De Stefano, Umberto Oreste, Maria Rosaria Coscia
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IgM is the major circulating Ig isotype in teleost fish, showing in Antarctic fish unique features such as an extraordinary long hinge region, which plays a crucial role in antibody structure and function. In this work, we describe the replacement of
Externí odkaz:
https://doaj.org/article/c4f7059914e1497192f161fffa2c433e
Autor:
Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been approved by the FDA
Externí odkaz:
https://doaj.org/article/827f7dff678649189f7f8c0f74c8e60f
Autor:
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger
Publikováno v:
Current Research in Physiology, Vol 7, Iss , Pp 100121- (2024)
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method
Externí odkaz:
https://doaj.org/article/676dd94ef0024c84ac2e9b4e8b0a1e30
Autor:
Sebastiaan C. de Graaf, Albert Bondt, Danique M. H. van Rijswijck, Hannah G. Juncker, Sien J. Mulleners, Mirjam J. A. Damen, Max Hoek, Britt J. van Keulen, Johannes B. van Goudoever, Albert J. R. Heck, Kelly A. Dingess
Publikováno v:
Frontiers in Nutrition, Vol 10 (2024)
IntroductionUpon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens that will end up in circulation. In lactating women such antibodies will also
Externí odkaz:
https://doaj.org/article/5e96a5bf2be6463bb05b7f835f7fbe78
Autor:
Hana Hanaee-Ahvaz, Monika Cserjan-Puschmann, Florian Mayer, Christopher Tauer, Bernd Albrecht, Paul G. Furtmüller, Birgit Wiltschi, Rainer Hahn, Gerald Striedner
Publikováno v:
Heliyon, Vol 9, Iss 12, Pp e22463- (2023)
Functionalization of proteins by incorporating reactive non-canonical amino acids (ncAAs) has been widely applied for numerous biological and therapeutic applications. The requirement not to lose the intrinsic properties of these proteins is often un
Externí odkaz:
https://doaj.org/article/2f2ce037de7743439e4ad4c7f4ffdc74
Autor:
Rui Zheng, Yuankun Chen, Yiting Zhang, Sixin Liang, Xiaojuan Zhao, Yiyi Wang, Pengju Wang, Ruotong Meng, Angang Yang, Bo Yan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors, and each component plays an important role in the function and anti-tumor efficacy. It has been reported that using human sequences or a low affinit
Externí odkaz:
https://doaj.org/article/ea0602e789f34a009dccaa014804a8ea
Autor:
Aaron M. D’Antona, Julie M. Lee, Melvin Zhang, Clarence Friedman, Tao He, Lidia Mosyak, Eric Bennett, Laura Lin, Maddison Silverman, Funi Cometa, Caryl Meade, Tyler Hageman, Eric Sousa, Justin Cohen, Kimberly Marquette, Darren Ferguson, Xiaotian Zhong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1931 (2024)
Structure and function of therapeutic antibodies can be modulated by a variety of post-translational modifications (PTM). Tyrosine (Tyr) sulfation is a type of negatively charged PTM that occurs during protein trafficking through the Golgi. In this s
Externí odkaz:
https://doaj.org/article/ee1664fedb7941809a1c37ea5cd17195
Autor:
Terence L. Kirley, Andrew B. Norman
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101520- (2023)
Fluorescein isothiocyanate (FITC) is widely used to fluorescently label reactive lysine residues on proteins, including antibodies. The rate and extent of labeling varies with reaction conditions, concentration of label, and the concentration and nat
Externí odkaz:
https://doaj.org/article/a19ddb72fc3b4d09aa9db90cc65c8d77
Autor:
Alexander B. Brummer, Agata Xella, Ryan Woodall, Vikram Adhikarla, Heyrim Cho, Margarita Gutova, Christine E. Brown, Russell C. Rockne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the development of cell-based cancer therapies, quantitative mathematical models of cellular interactions are instrumental in understanding treatment efficacy. Efforts to validate and interpret mathematical models of cancer cell growth and death h
Externí odkaz:
https://doaj.org/article/3ed9f3f43ccd4e5b86bbe4ee26323978
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16967 (2023)
The analytical applications of antibodies are often associated with their immobilization on different carriers, which is accompanied by a loss of antigen-binding activity for a sufficient proportion of the bound antibodies. In contrast to data on pla
Externí odkaz:
https://doaj.org/article/6c0c40608f6e4ad09686303870ca308a