Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Autor: Sharon R Lewin, Rachel D. Pascoe, Rémi Fromentin, Paul U. Cameron, Ashanti Dantanarayana, Celine Gubser, Thomas A Rasmussen, Lydie Trautman, Ajantha Solomon, Christopher Chiu, Vanessa A. Evans, James H McMahon, Judy Chang, Nicolas Chomont

Publikováno v: Chiu, C Y, Chang, J J, Dantanarayana, A I, Solomon, A, Evans, V A, Pascoe, R, Gubser, C, Trautman, L, Fromentin, R, Chomont, N, McMahon, J H, Cameron, P U, Rasmussen, T A & Lewin, S R 2022, ' Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy ', Journal of Immunology, vol. 208, no. 1, pp. 54-62 . https://doi.org/10.4049/jimmunol.2100367
J Immunol

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune checkpoint (IC) proteins on total and HIV-specific T-cells. Reversing immune exhaustion is one strategy to enhance the elim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bbff23e6545b23bc265b80b828ee9c
https://pure.au.dk/portal/da/publications/combination-immune-checkpoint-blockade-enhances-il2-and-cd107a-production-from-hivspecific-t-cells-ex-vivo-in-people-living-with-hiv-on-antiretroviral-therapy(b1e04674-c9d9-4b2c-85ec-4cc0210d139f).html

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

Autor: Susana Fiorentino, Paola Lasso, Alena Donda, Alfonso Barreto, Pedro Romero, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Claudia Urueña

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in immunology, vol. 11, pp. 584959

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a6aba6eaf8909975566225f669d5aa
https://www.frontiersin.org/articles/10.3389/fimmu.2020.584959/full

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Autor: Laurence Pearmain, Andrew Ustianowski, Ling Pei Ho, Syed Murtuza Baker, Thomas Williams, Joanna Porter, Hannah Durrington, Saba Khan, Nawar Diar Bakerly, Angela Simpson, Sean Knight, Alistair Chenery, Magnus Rattray, Alex Horsley, Ratko Djukanovic, Nicholas Scott, Paul Dark, Siddharth Krishnan, Alexander G Mathioudakis, Tovah Shaw, Chris Brightling, Madhvi Menon, Tracy Hussell, Oliver Brand

Publikováno v: Mann, E R, Menon, M, Knight, S B, Konkel, J E, Jagger, C, Shaw, T N, Krishnan, S, Rattray, M, Ustianowski, A, Bakerly, N D, Dark, P, Lord, G, Simpson, A, Felton, T, Ho, L-P, Feldmann, M, Grainger, J R, Hussell, T, Scott, N & Mathioudakis, A 2020, ' Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 ', Science Immunology, vol. 5, no. 51, eabd6197 . https://doi.org/10.1126/sciimmunol.abd6197
Science Immunology

Longitudinal analysis of the immune response in COVID-19 patients identifies a myeloid signature associated with severe disease.
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfab62bee102280763bee0731112226
https://research.manchester.ac.uk/en/publications/8e5b901d-e869-40f3-a705-a789eeac22ca

The Dysfunctional Immune System in Common Variable Immunodeficiency Increases the Susceptibility to Gastric Cancer

Autor: Rita Câmara, Carla Oliveira, Gilza Gonçalves, Catarina Costa, Emília Faria, Ana E. Sousa, Sara P. Silva, Susana L. Silva, Cristina Ferreira, José Torres da Costa, José Carlos Machado, Irene Gullo, Fátima Carneiro, Ruben Duarte Ferreira, Pedro Rosmaninho, Adriana Motta, João Santos-Antunes

Publikováno v: Cells
Cells, Vol 9, Iss 1498, p 1498 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Volume 9
Issue 6

Gastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55205557188c40fae8af451a86c16d3
http://europepmc.org/articles/PMC7349552

CD11c-targeted delivery of DNA to dendritic cells leads to cGAS- and STING-dependent maturation

Autor: Martin R. Jakobsen, Marlene Fyrstenberg Laursen, Kasper L Jønsson, Emil Kofod-Olsen, Laura L. T. Degn, Ralf Agger, Esben Christensen

Publikováno v: Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted delivery of DNA to dendritic cells leads to cGAS-and STING-dependent maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS-and STING-dependent Maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195

Immunotherapeutic activation of tumor-specific T cells has proven to be an interesting approach in anticancer treatment. Particularly, anti-CTLA-4 and anti-PD-1/PD-L1 treatment looks promising, and conceivably, even better clinical results might be o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37f02769d1f22d36d14f7ee681e1770
https://vbn.aau.dk/da/publications/ddd85507-dcfc-45ee-88b7-647758443f7e