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pro vyhledávání: '"Anticoagulants/*administration & dosage/*adverse effects/pharmacokinetics"'
Autor:
Patrice Jaillon, Sandrine Morin, Marie-Anne Loriot, Laurent Becquemont, Céline Verstuyft, Annie Robert, Antoine Flahault, Philippe Beaune, Christian Funck-Brentano
Publikováno v:
European Journal of Clinical Pharmacology, Vol. 58, No 11 (2003) pp. 739-45
Cytochrome P 450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. To determine the relative frequencies of dif