Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Antibody validation"'
Autor:
M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow, H.S. Virk
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Antibodies are one of the most important reagents used in biomedical and fundamental research, used to identify, and quantify proteins, contribute to knowledge of disease mechanisms, and validate drug targets. Yet many antibodies used in research do
Externí odkaz:
https://doaj.org/article/37657410713a47738873faec0a812995
Autor:
Claudio Peter D’Incal, Elisa Cappuyns, Kaoutar Choukri, Kevin De Man, Kristy Szrama, Anthony Konings, Lina Bastini, Kim Van Meel, Amber Buys, Michele Gabriele, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Fabio Mohn, Marc Bühler, Nathalie Van der Aa, Anke Van Dijck, R. Frank Kooy, Wim Vanden Berghe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Heterozygous de novo mutations in the Activity-Dependent Neuroprotective Homeobox (ADNP) gene underlie Helsmoortel-Van der Aa syndrome (HVDAS). Most of these mutations are situated in the last exon and we previously demonstrated escape from
Externí odkaz:
https://doaj.org/article/f7c381ec5b634584bcd2d05f0e32ea1f
Autor:
Vera Ruíz Moleón, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende
Publikováno v:
F1000Research, Vol 13 (2024)
Casein kinase II subunit alpha (CSNK2A1), a serine/threonine kinase, phosphorylates multiple protein substrates and is involved in diverse cellular and biological processes. Implicated in various human diseases, high-performing antibodies would help
Externí odkaz:
https://doaj.org/article/45ad08922ff5439a818a4fcd4d501bfd
Autor:
Vera Ruíz Moleón, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Charles Alende, Maryam Fotouhi
Publikováno v:
F1000Research, Vol 13 (2024)
Rab10 is a small GTPase involved in cargo transport from the trans-Golgi network to the plasma membrane and endocytic recycling back to the cell membrane. It has garnered significant interest in neurodegenerative disease research, particularly due to
Externí odkaz:
https://doaj.org/article/1d5d357aa8c649cc932c930a73d5ad07
Autor:
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Walaa Alshalfie, Harvinder Virk, Zhipeng You, Carolyn Jones, Michael Biddle
Publikováno v:
F1000Research, Vol 12 (2024)
RNA-binding protein Fused-in Sarcoma (FUS) plays an essential role in various cellular processes. Mutations in the C-terminal domain region, where the nuclear localization signal (NLS) is located, causes the redistribution of FUS from the nucleus to
Externí odkaz:
https://doaj.org/article/64d8deecdefb4a53ac5fa2837cb1e422
Publikováno v:
F1000Research, Vol 12 (2024)
SPARC-related modular calcium-binding protein 1, otherwise known as SMOC-1, is a secreted glycoprotein involved in various cell biological processes including cell-matrix interactions, osteoblast differentiation, embryonic development, and homeostasi
Externí odkaz:
https://doaj.org/article/d715eab9312d411a947b6941bfa5aba1
Autor:
Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Publikováno v:
F1000Research, Vol 13 (2024)
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disord
Externí odkaz:
https://doaj.org/article/4a5893b8570c4bb6a47f872075702b74
Autor:
Richard A Kahn, Harvinder Virk, Carl Laflamme, Douglas W Houston, Nicole K Polinski, Rob Meijers, Allan I Levey, Clifford B Saper, Timothy M Errington, Rachel E Turn, Anita Bandrowski, James S Trimmer, Meghan Rego, Leonard P Freedman, Fortunato Ferrara, Andrew RM Bradbury, Hannah Cable, Skye Longworth
Publikováno v:
eLife, Vol 13 (2024)
Antibodies are used in many areas of biomedical and clinical research, but many of these antibodies have not been adequately characterized, which casts doubt on the results reported in many scientific papers. This problem is compounded by a lack of s
Externí odkaz:
https://doaj.org/article/0b65acdfb7aa48e3af7059256f37ae20
Publikováno v:
F1000Research, Vol 12 (2024)
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research
Externí odkaz:
https://doaj.org/article/c30ab8b2fbfe4f2092198a5d29419ef1
Autor:
Carl Laflamme, Kathleen Southern, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Harvinder Virk, Carolyn Jones, Michael S. Biddle
Publikováno v:
F1000Research, Vol 13 (2024)
Synaptotagmin-1 is a synaptic vesicle transmembrane protein that senses calcium influx via its tandem C2-domains, triggering synchronous neurotransmitter release. Disruption to SYT1 is associated with neurodevelopmental disorders, highlighting the im
Externí odkaz:
https://doaj.org/article/3a714eae297445a9a3cc323e3a153d08