Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Antibody structure"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Antibodies play a crucial role in disease treatment, leveraging their ability to selectively interact with the specific antigen. However, screening antibody gene sequences for target antigens via biological experiments is extremel
Externí odkaz:
https://doaj.org/article/d2d7272e96f8483ca3b423e8c299a583
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTAntibodies have increasingly been developed as drugs with over 100 now licensed in the US or EU. During development, it is often necessary to increase or reduce the affinity of an antibody and rational attempts to do so rely on having a struc
Externí odkaz:
https://doaj.org/article/ea0ff2b1ed564d10a991b78706b3b6b9
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-based immune checkpoint blockade (ICB)-based therapeutics have become effective clinical applications for cancers. Applications of monoclonal antibodies (mAbs) to de-activate the PD-1-PD-L1 pathway could effectively reverse the pheno
Externí odkaz:
https://doaj.org/article/2d2522248ef648fd90bc155223e64b00
Autor:
Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane, Klaus R. Liedl
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAdvances in structural biology and the exponential increase in the amount of high-quality experimental structural data available in the Protein Data Bank has motivated numerous studies to tackle the grand challenge of predicting protein struc
Externí odkaz:
https://doaj.org/article/3a42b424031444ed92eeaed275b5f9d3
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2412-2422 (2022)
The devastating economic and public health consequences caused by the COVID-19 pandemic have prompted outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Those effo
Externí odkaz:
https://doaj.org/article/9092f0f2ad3a4a06aced5fbf51323e67
Autor:
Igor Jaszczyszyn, Weronika Bielska, Tomasz Gawlowski, Pawel Dudzic, Tadeusz Satława, Jarosław Kończak, Wiktoria Wilman, Bartosz Janusz, Sonia Wróbel, Dawid Chomicz, Jacob D. Galson, Jinwoo Leem, Sebastian Kelm, Konrad Krawczyk
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
AlphaFold2 has hallmarked a generational improvement in protein structure prediction. In particular, advances in antibody structure prediction have provided a highly translatable impact on drug discovery. Though AlphaFold2 laid the groundwork for all
Externí odkaz:
https://doaj.org/article/b9bf830784aa46f6b4415c0e2d6b8f50
Akademický článek
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Publikováno v:
Asian Journal of Surgery, Vol 46, Iss 6, Pp 2552-2553 (2023)
Externí odkaz:
https://doaj.org/article/54a348cdc9764237bbd0507db4376021
Autor:
Monica L. Fernández-Quintero, Nancy D. Pomarici, Anna-Lena M. Fischer, Valentin J. Hoerschinger, Katharina B. Kroell, Jakob R. Riccabona, Anna S. Kamenik, Johannes R. Loeffler, James A. Ferguson, Hailee R. Perrett, Klaus R. Liedl, Julianna Han, Andrew B. Ward
Publikováno v:
Antibodies, Vol 12, Iss 4, p 67 (2023)
Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their molecular recognition is cr
Externí odkaz:
https://doaj.org/article/ebfea549dcaf49caafa4ea894542b32c
Akademický článek
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