Redirecting a Broad-Spectrum Nanobody Against the Receptor-Binding Domain of SARS-CoV-2 to Target Omicron Variants

Autor: Kwanpet Intasurat, Nonth Submunkongtawee, Phoomintara Longsompurana, Apisitt Thaiprayoon, Warisara Kasemsukwimol, Suwitchaya Sirimanakul, Siriphan Boonsilp, Supaphron Seetaha, Kiattawee Choowongkomon, Dujduan Waraho-Zhmayev

Publikováno v: Applied Sciences, Vol 14, Iss 22, p 10548 (2024)

The urgent need for an effective COVID-19 therapy has propelled the exploration of innovative strategies to combat the fast-mutating SARS-CoV-2 virus. This study attempted to develop nanobodies (Nbs) against the SARS-CoV-2 Omicron variants by redirec

Externí odkaz: https://doaj.org/article/c214d5353d734eceba81fc6dc323f794

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In vivo Phage Display: A promising selection strategy for the improvement of antibody targeting and drug delivery properties

Autor: Ana S. André, Isa Moutinho, Joana N. R. Dias, Frederico Aires-da-Silva

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

The discovery of hybridoma technology, described by Kohler and Milstein in 1975, and the resulting ability to generate monoclonal antibodies (mAbs) initiated a new era in antibody research and clinical development. However, limitations of the hybrido

Externí odkaz: https://doaj.org/article/123a998e52ef41de80fa85bbf91ca29a

Aflatoxin-specific monoclonal antibody selection for immunoaffinity column development

Autor: Özlem Ertekin, Tuğrul Kaymak, Şerife Şeyda Pirinçci, Esin Akçael, Selma Öztürk

Publikováno v: BioTechniques, Vol 66, Iss 6, Pp 261-268 (2019)

Antibodies are the basic components of immunoanalytical systems used for detection of a wide range of analytes. Although there are some ground rules for antibody selection, analyte- and assay-specific criteria are the ones that determine the ultimate

Externí odkaz: https://doaj.org/article/c2aae111a6634de19ab24cc4423040f7

A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display

Autor: Rimbault, Charlotte, Knudsen, Pelle D., Damsbo, Anna, Boddum, Kim, Ali, Hanif, Hackney, Celeste M., Ellgaard, Lars, Bohn, Markus-Frederik, Laustsen, Andreas H.

Publikováno v: Rimbault, C, Knudsen, P D, Damsbo, A, Boddum, K, Ali, H, Hackney, C M, Ellgaard, L, Bohn, M-F & Laustsen, A H 2023, ' A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display ', New Biotechnology, vol. 76, pp. 23-32 . https://doi.org/10.1016/j.nbt.2023.04.002

Phage display technology is a powerful tool for selecting monoclonal antibodies against a diverse set of antigens. Within toxinology, however, it remains challenging to generate monoclonal antibodies against many animal toxins, as they are difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926277cb7e0ea611b7a76678ea42e024
https://curis.ku.dk/portal/da/publications/a-singlechain-variable-fragment-selected-against-a-conformational-epitope-of-a-recombinantly-produced-snake-toxin-using-phage-display(1b9d42e1-ce5f-4377-b809-6542d6df2d83).html