Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Antibody repertoires"'
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The antibody drug field has continually sought improvements to methods for candidate discovery and engineering. Historically, most such methods have been laboratory-based, but informatics methods have recently started to make an impact. Deep learning
Externí odkaz:
https://doaj.org/article/4acccd0633eb4a30a55c0019db29197d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unb
Externí odkaz:
https://doaj.org/article/9e0450544bb94672b3c0bf4034833577
Publikováno v:
Viruses, Vol 15, Iss 2, p 374 (2023)
The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a
Externí odkaz:
https://doaj.org/article/17b2de0319ac4b959b696aab91b75c23
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matias F. Gutierrez-Gonzalez, Brandon J. Dekosky, Kayla G. Sprenger, Timothy A. Whitehead
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mA
Externí odkaz:
https://doaj.org/article/10a36cfa20ad4ada87c052c6b7e5c904
Autor:
Hemangi B. Shah, Kenneth Smith, Jonathan D. Wren, Carol F. Webb, Jimmy D. Ballard, Rebecka L. Bourn, Judith A. James, Mark L. Lang
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid an
Externí odkaz:
https://doaj.org/article/d862c4c39e984e979e1d489eea68de97
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2016 Jul 01. 113(28), 7846-7851.
Externí odkaz:
https://www.jstor.org/stable/26470806
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Feb 01. 112(6), 1815-1820.
Externí odkaz:
https://www.jstor.org/stable/26461513
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Fabricio Montalvão, Danielle Oliveira Nascimento, Marise P. Nunes, Carolina M. Koeller, Alexandre Morrot, Leticia Miranda S. Lery, Paulo M. Bisch, Santuza M. R. Teixeira, Rita Vasconcellos, Leonardo Freire-de-Lima, Marcela F. Lopes, Norton Heise, George A. DosReis, Célio Geraldo Freire-de-Lima
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts. By
Externí odkaz:
https://doaj.org/article/c879b508b68d4d519a59f4bbbf34b088