Zobrazeno 1 - 10
of 1 649
pro vyhledávání: '"Antibody dependent cellular cytotoxicity"'
Autor:
Sylvia Zöphel, Nadja Küchler, Johanna Jansky, Cora Hoxha, Gertrud Schäfer, Julius J. Weise, Joanne Vialle, Lea Kaschek, Gebhard Stopper, Hermann Eichler, Daniela Yildiz, Alina Moter, Philipp Wendel, Evelyn Ullrich, Claudia Schormann, Torben Rixecker, Onur Cetin, Frank Neumann, Patrick Orth, Moritz Bewarder, Markus Hoth, Lorenz Thurner, Eva C. Schwarz
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Assessing the prognosis of patients with aggressive non-Hodgkin B cell lymphoma mainly relies on a clinical risk score (IPI). Standard first-line therapies are based on a chemo-immunotherapy with rituximab, which mediates CD16-dependent anti
Externí odkaz:
https://doaj.org/article/c26da19e6df140a2bd9fa86950fc9b73
Autor:
Yibo Tang, Kaiming Tang, Yunqi Hu, Zi-Wei Ye, Wanyu Luo, Cuiting Luo, Hehe Cao, Ran Wang, Xinyu Yue, Dejian Liu, Cuicui Liu, Xingyi Ge, Tianlong Liu, Yaoqing Chen, Shuofeng Yuan, Lei Deng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe frequent occurrence of mutations in the SARS-CoV-2 Spike (S) protein, with up to dozens of mutations, poses a severe threat to the current efficacy of authorized COVID-19 vaccines. Membrane (M) protein, which is the most abundant vira
Externí odkaz:
https://doaj.org/article/eed85f45390a42399012fa3608b922f9
Autor:
Yunfang Li, Jianming Wu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD177 plays an important role in the proliferation and differentiation of myeloid lineage cells including neutrophils, myelocytes, promyelocytes, megakaryocytes, and early erythroblasts in bone marrow. CD177 deficiency is a common phenotype in humans
Externí odkaz:
https://doaj.org/article/991d525a026c44adbba268ee2233eaef
Autor:
Kate J. Dixon, Kristin M. Snyder, Melissa Khaw, Robert Hullsiek, Zachary B. Davis, Anders W. Matson, Soheila Shirinbak, Bryan Hancock, Ryan Bjordahl, Martin Hosking, Jeffrey S. Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNK cells can mediate tumor cell killing by natural cytotoxicity and by antibody-dependent cell-mediated cytotoxicity (ADCC), an anti-tumor mechanism mediated through the IgG Fc receptor CD16A (FcγRIIIA). CD16A polymorphisms conferring in
Externí odkaz:
https://doaj.org/article/25f0bc6b630e4c64ae1fcc8be73d5e42
Autor:
Austin T.K. Hoke, Yoko Takahashi, Michelle R. Padget, Javier Gomez, Moran Amit, Jared Burks, Diana Bell, Tongxin Xie, Patrick Soon-Shiong, James W. Hodge, Ehab Y. Hanna, Nyall R. London, Jr
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101943- (2024)
Purpose: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of the sinonasal cavity with poor prognosis and limited treatment options. To investigate the potential for SNUC sensitivity to combinatory immunotherapy, we perfor
Externí odkaz:
https://doaj.org/article/21390839f1884ba499e36505b6266d78
Autor:
Panagiota Bouti, Bart J. A. M. Klein, Paul J. H. Verkuijlen, Karin Schornagel, Floris P. J. van Alphen, Kees-Karel H. Taris, Maartje van den Biggelaar, Arie J. Hoogendijk, Robin van Bruggen, Taco W. Kuijpers, Hanke L. Matlung
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orches
Externí odkaz:
https://doaj.org/article/53bd94c6190c4bc09c41a6251de19372
Autor:
Daniel Fernández-Soto, Álvaro F. García-Jiménez, José M. Casasnovas, Mar Valés-Gómez, Hugh T. Reyburn
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionIt is now clear that coronavirus disease 19 (COVID-19) severity is associated with a dysregulated immune response, but the relative contributions of different immune cells is still not fully understood. SARS CoV-2 infection triggers marke
Externí odkaz:
https://doaj.org/article/393746ad871c479da14e43b119e05dbb
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7734-7748 (2023)
The clinically approved human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibodies (mAbs), trastuzumab, and pertuzumab, target domains IV and II, respectively. Trastuzumab is now the standard treatment for HER2-overexpressed brea
Externí odkaz:
https://doaj.org/article/d81dcae4187f4e6dbb684db1d0f8414e
Autor:
Titus Abiola Olukitibi, Zhujun Ao, Hiva Azizi, Maggie J Ouyang, Tosin Omole, Lyle McKinnon, Darwyn Kobasa, Kevin Coombs, Gary Kobinger, Xiaojian Yao
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 195 (2024)
Background: To investigate the immune responses and protection ability of ultraviolet light (UV)-inactivated recombinant vesicular stomatitis (rVSV)-based vectors that expressed a fusion protein consisting of four copies of the influenza matrix 2 pro
Externí odkaz:
https://doaj.org/article/342935da837c418f855fbf905f428222
Autor:
André Luiz Lourenço, Shih-Wei Chuo, Markus F. Bohn, Byron Hann, Shireen Khan, Neha Yevalekar, Nitin Patel, Teddy Yang, Lina Xu, Dandan Lv, Robert Drakas, Sarah Lively, Charles S. Craik
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe urokinase-type plasminogen activator receptor (uPAR) is an essential regulator for cell signaling in tumor cell proliferation, adhesion, and metastasis. The ubiquitous nature of uPAR in many aggressive cancer types makes uPAR an attractiv
Externí odkaz:
https://doaj.org/article/069d547a08b64d7f92e26a8d69854d53