Zobrazeno 1 - 10
of 1 396
pro vyhledávání: '"Antibody antigen"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Antibodies play a crucial role in disease treatment, leveraging their ability to selectively interact with the specific antigen. However, screening antibody gene sequences for target antigens via biological experiments is extremel
Externí odkaz:
https://doaj.org/article/d2d7272e96f8483ca3b423e8c299a583
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/0c3bf6293fd040d4abf7e79003dcb773
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer and autoimmune diseas
Externí odkaz:
https://doaj.org/article/9a103dbc8e0c417bac667efb7fe77024
Autor:
Tomasz Guszcz, Anna Sankiewicz, Lech Gałek, Ewelina Chilinska-Kopko, Adam Hermanowicz, Ewa Gorodkiewicz
Publikováno v:
Sensors, Vol 24, Iss 19, p 6371 (2024)
Laminin, fibronectin, and collagen IV are pivotal extracellular matrix (ECM) components. The ECM environment governs the fundamental properties of tumors, including proliferation, vascularization, and invasion. Given the critical role of cell-matrix
Externí odkaz:
https://doaj.org/article/a9d55f6052e542ff9767a713fb8a1ba3
Autor:
Oscar Mejias-Gomez, Andreas V. Madsen, Kerstin Skovgaard, Lasse E. Pedersen, J. Preben Morth, Timothy P. Jenkins, Peter Kristensen, Steffen Goletz
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe human immune system uses antibodies to neutralize foreign antigens. They are composed of heavy and light chains, both with constant and variable regions. The variable region has six hypervariable loops, also known as complementary-determi
Externí odkaz:
https://doaj.org/article/457ebf9018dd4c70bbe8e1d0e7fa743e
Autor:
Feng Ni, Cunle Wu, Ping Xu, Ping Wang, Yves Fortin, Melanie Arbour, Luke Masson, Denis L’Abbé, Andrea Acel, Mylene Gosselin, Anne E.G. Lenferink
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTCarbonic anhydrase (CA)-IX is an extracellular enzyme that is essential in the adaptation of tumor cells to their increasingly more hypoxic and acidic microenvironment. Within the family of carbonic anhydrases, CA-IX is unique in that it is t
Externí odkaz:
https://doaj.org/article/bef68df9eb5940de9d22b6603ddf4189
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-based immune checkpoint blockade (ICB)-based therapeutics have become effective clinical applications for cancers. Applications of monoclonal antibodies (mAbs) to de-activate the PD-1-PD-L1 pathway could effectively reverse the pheno
Externí odkaz:
https://doaj.org/article/2d2522248ef648fd90bc155223e64b00
Publikováno v:
Royal Society Open Science, Vol 10, Iss 11 (2023)
Cellulose paper-based sensing devices have shown promise in addressing the accuracy, sensitivity, selectivity, analysis time and cost of current disease diagnostic tools owing to their excellent physical and physiochemical properties, high surface-ar
Externí odkaz:
https://doaj.org/article/a01f6f69a2e647d18d30e0814d5a90f2
Autor:
Terence L. Kirley, Andrew B. Norman
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101520- (2023)
Fluorescein isothiocyanate (FITC) is widely used to fluorescently label reactive lysine residues on proteins, including antibodies. The rate and extent of labeling varies with reaction conditions, concentration of label, and the concentration and nat
Externí odkaz:
https://doaj.org/article/a19ddb72fc3b4d09aa9db90cc65c8d77
Autor:
Jagat Adhikari, James Heffernan, Melissa Edeling, Estefania Fernandez, Prashant N. Jethva, Michael S. Diamond, Daved H. Fremont, Michael L. Gross
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 374 (2024)
Japanese encephalitis virus (JEV) remains a global public health concern due to its epidemiological distribution and the existence of multiple strains. Neutralizing antibodies against this infection have shown efficacy in in vivo studies. Thus, eluci
Externí odkaz:
https://doaj.org/article/eb43680e76c24949abc9fd9bd793d91c