Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells

Autor: Simon Paulos, F. Eun-Hyung Lee, Gowrisankar Rajam, Srinivasan Velusamy, John L. Daiss, Richard P. Ramonell, Shuya Kyu, Ann R. Falsey, Colleen S. Kraft, Merin Kuruvilla, Edward E. Walsh, Yun F. Wang, Hao Wu

Publikováno v: PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259644 (2021)

Background Streptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to introduce definitive therapy potentially improving patient outcomes. Methods We introduce two ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cedf87eb6a5ff1f9e9c4b5351687a04
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589192/?tool=EBI

Robustification of RosettaAntibody and Rosetta SnugDock

Autor: Jeliazko R. Jeliazkov, Jeffrey J. Gray, Rahel Frick, Jing Zhou

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0234282 (2021)
PLoS ONE

In recent years, the observed antibody sequence space has grown exponentially due to advances in high-throughput sequencing of immune receptors. The rise in sequences has not been mirrored by a rise in structures, as experimental structure determinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996a0ef4580f2147d0aa9a174bece671
https://doaj.org/article/038ef854a5e249eb821b8650f79d2e38

Pharmacokinetic comparison of a diverse panel of non-targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non-human primates

Autor: Marcus Soto, Hossein Salimi-Moosavi, Frederick W. Jacobsen, John O. Hui, Gregory E. Arnold, Qing Chen, Kenneth W. Walker

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217061 (2019)

In this study we compared the pharmacokinetic profile of four unrelated antibodies, which do not bind to mammalian antigens, in IgG1 and IgG2 frameworks in both rats and non-human primates (NHP). This allowed for extensive cross comparison of the imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f455a19d1cec86012ec17bc3e904d
http://europepmc.org/articles/PMC6533040

Generation and characterization of D-dimer specific monoclonal antibodies for use in latex agglutination test

Autor: Beáta Török-Nagy, Béla Dénes, József Antal

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0212104 (2019)

The commercially available D-dimer assays used in the clinical practice often show differences in the results, and their specificity and sensitivity are rather unsatisfactory. Our aim was to develop a new monoclonal antibody against D-dimer with a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90922d8abb6dd2f00a8a420cdfadcc0
http://europepmc.org/articles/PMC6375587

Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children

Autor: Asger M. Frank, Lea Barfod, Frederica D. Partey, Melanie R. Walker, Michael F. Ofori, Lars Hviid, Filip C. Castberg, Anne Knudsen, Edem W. Sarbah, Maria Rosaria Bassi

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243943 (2020)
Walker, M R, Knudsen, A S, Partey, F D, Bassi, M R, Frank, A M, Castberg, F C, Sarbah, E W, Ofori, M F, Hviid, L & Barfod, L 2020, ' Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children ', PLoS ONE, vol. 15, no. 12, pp. e0243943 . https://doi.org/10.1371/journal.pone.0243943

Developing a vaccine againstPlasmodium falciparummalaria has been challenging, primarily due to high levels of antigen polymorphism and a complex parasite lifecycle. Immunization with theP.falciparummerozoite antigens PfMSRP5, PfSERA9, PfRAMA, PfCyRP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e432ca8b1ce5563cc64223e32953ef
https://doi.org/10.1371/journal.pone.0243943