A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa

Autor: Germán Bou, Miriam Moscoso, Patricia García, Víctor Fuentes-Valverde, Manuel Vilanova, Fátima Gärtner, Juan A. Vallejo, Alexandra Correia, Mónica Francisco-Tomé, Maria P Cabral, Astrid Pérez

Publikováno v: PLoS Pathogens, Vol 16, Iss 2, p e1008311 (2020)
PLoS Pathogens

Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b71f6cf116c27ff394518a3c649af98
https://doaj.org/article/cf9aa37cc0a545c399d07715a5affa04

Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG

Autor: Reglinski, Mark, Lynskey, Nicola N., Choi, Yoon Jung, Edwards, Robert J., Sriskandan, Shiranee

Publikováno v: The Journal of Infection
Reglinski, M, Lynskey, N N, Choi, Y J, Edwards, R J & Sriskandan, S 2016, ' Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG ', Journal of Infection, vol. 72, no. 4, pp. 450-9 . https://doi.org/10.1016/j.jinf.2016.02.002

Summary Objectives Despite over a century of research and the careful scrutiny of many promising targets, there is currently no vaccine available for the prevention of Streptococcus pyogenes infection. Through analysis of the protective, anti-strepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::21b87ae228768c2fc0fd2955ec1a262d
http://europepmc.org/articles/PMC4796040

Antibodies Targeting Hsa and PadA Prevent Platelet Aggregation and Protect Rats against Experimental Endocarditis Induced by Streptococcus gordonii

Autor: Frank Oechslin, José M. Entenza, Stefano Mancini, Philippe Moreillon, Carmen Menzi

Publikováno v: Infection and immunity, vol. 84, no. 12, pp. 3557-3563

Streptococcus gordonii and related species of oral viridans group streptococci (VGS) are common etiological agents of infective endocarditis (IE). We explored vaccination as a strategy to prevent VGS-IE, using a novel antigen-presenting system based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7ba4cb09d45b7d61d03a7ba239eb6b
https://serval.unil.ch/notice/serval:BIB_5B99C2BFE32C

The B-cell response to a primary and booster course of MenACWY-CRM₁₉₇ vaccine administered at 2, 4 and 12 months of age

Autor: Blanchard Rohner, Géraldine, Snape, Matthew D, Kelly, Dominic F, O'Connor, Daniel, John, Tessa, Clutterbuck, Elizabeth A, Ohene-Kena, Brigitte, Klinger, Chaam L, Odrljin, Tatjana, Pollard, Andrew J

Publikováno v: Vaccine, Vol. 31, No 20 (2013) pp. 2441-2448

A quadrivalent meningococcal vaccine conjugated to CRM197 (MenACWY-CRM197) is immunogenic in young infants. We assessed the memory B-cell and antibody responses after a primary and booster course of MenACWY-CRM197 in children. At 5 months of age, fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::66c3cb2095e6ec21333d3f7e7f0eafc5
https://pubmed.ncbi.nlm.nih.gov/23566945

Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?

Autor: Cedric Sottas, Paul-Henri Lambert, Jean Taguebue, Claude Lecoultre, Marie Kobela, Klara M. Posfay-Barbe, Stéphane Grillet, Claire-Anne Siegrist, Tetanye Ekoe

Publikováno v: Vaccine, Vol. 28, No 27 (2010) pp. 4356-4361

To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0680b98fcc1f7c6d8f7b5d564f60756f
https://pubmed.ncbi.nlm.nih.gov/20447475