Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Antibacterial drug discovery"'
Autor:
Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105073- (2024)
Summary: Background: The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified by the World Health Organization (WHO) as a global health priority. N
Externí odkaz:
https://doaj.org/article/eaf98873ad5c42ceacfa2d3e86721587
Publikováno v:
Antibiotics, Vol 12, Iss 11, p 1607 (2023)
Antimicrobial drug resistance has emerged as a significant challenge in contemporary medicine due to the proliferation of numerous bacterial strains resistant to all existing antibiotics. Meanwhile, riboswitches have emerged as promising targets for
Externí odkaz:
https://doaj.org/article/91ba2d0e2bec4801b0be3b12ce4107ad
Autor:
Samuel Njikan, Sara Ahmed, Alyssa Manning, Divya Awasthi, Yulia Ovechkina, Sultan Chowdhury, Arielle Butts, Tanya Parish
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT We previously identified a phenylthiourea series with activity against intracellular Mycobacterium tuberculosis using a high-throughput, high-content assay. We conducted a catalog structure-activity relationship study with a collection of 35
Externí odkaz:
https://doaj.org/article/090d2ea5e04c4e568d67834553051996
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1770 (2022)
It is urgent to find new antibiotic classes against multidrug-resistant bacteria as the rate of discovery of new classes of antibiotics has been very slow in the last 50 years. Recently, pyrrolobenzodiazepines (PBDs) with a C8-linked aliphatic-hetero
Externí odkaz:
https://doaj.org/article/e9fbd5f3717f4aa1919f5625b8a644cf
Autor:
Federica A. Falchi, Giorgia Borlotti, Francesco Ferretti, Gianvito Pellegrino, Matteo Raneri, Marco Schiavoni, Alessandro Caselli, Federica Briani
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Interfering with the ability of pathogenic bacteria to import glucose may represent a new promising antibacterial strategy, especially for the treatment of infections occurring in diabetic and other hyperglycemic patients. Such patients are particula
Externí odkaz:
https://doaj.org/article/42ad6d2378e54a3985c27598685351fd
Autor:
Nikolet Pavlova, Robert Penchovsky
Publikováno v:
Antibiotics, Vol 11, Iss 9, p 1177 (2022)
Antibiotic resistance (AR) is an acute problem that results in prolonged and debilitating illnesses. AR mortality worldwide is growing and causes a pressing need to research novel mechanisms of action and untested target molecules. This article prese
Externí odkaz:
https://doaj.org/article/779b43875dd1467ca87361c7bfc4f818
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Navid Jubaer
Publikováno v:
Applied Microbiology
Volume 3
Issue 1
Pages: 104-118
Volume 3
Issue 1
Pages: 104-118
Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases. Exposure to microbes can also occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2ea705ebf881b1227a7533e8a17d60
https://doi.org/10.3390/applmicrobiol3010009
https://doi.org/10.3390/applmicrobiol3010009
Publikováno v:
Volume: 25, Issue: 1 19-24
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
Bakteriyel enfeksiyonlarda ilaç direnci frekansındaki artış, yeni mekanizmaları hedefleyen yeni antibakteriyel ajanların araştırılmasına yol açmıştır. NAD+-bağımlı DNA ligazın fonksiyonlarının bir çoğu, onu antibakteriyel ilaç
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abcfa06c0ff591c5b40edd6b958a9fb
https://doi.org/10.18016/ksutarimdoga.vi.884279
https://doi.org/10.18016/ksutarimdoga.vi.884279
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.