Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin

Autor: Habib Karoui, Kenneth J. Clemetson, Timothy N. C. Wells, Houcemeddine Othman, Soumaya Souid, José Neptuno Rodríguez-López, Ichrak Riahi-Chebbi, Zohra Aloui, Ammar Gasmi, Edith M. Magnenat, Najet Srairi-Abid, Khadija Essafi-Benkhadir, Manel B Hammouda

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (3), pp.600--614. ⟨10.1016/j.bbagen.2017.11.019⟩

Background The resistance of melanoma cells to cisplatin restricts its clinical use. Therefore, the search for novel tumor inhibitors and effective combination treatments that sensitize tumor cells to this drug are still needed. We purified macrovipe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f1c617f4ea3f5dfa760615b6a3fee6
https://doi.org/10.1016/j.bbagen.2017.11.019

Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy

Autor: Sami Fattouch, Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, Khadija Essafi-Benkhadir, Habib Karoui, Ons Zakraoui

Publikováno v: Cancer Cell International
Cancer Cell International, BioMed Central, 2015, 16 (1), pp.1. ⟨10.1186/s12935-016-0276-7⟩

Background Development of alternative cancer-specific drugs would be of paramount importance to overcome toxicity toward normal tissues and tumor resistance. Here, we investigated the potential anti-tumoral effect of peel (Peph) and pulp polyphenolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e264b17c7ccade0174c06068a53357
https://doi.org/10.1186/s12935-016-0276-7

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Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

Autor: Markus Hoffmann, Tibor Görögh, Elgar Susanne Quabius, Petra Ambrosch, Lászlo Béress

Publikováno v: Molecular Cancer, Vol 12, Iss 1, p 12 (2013)
Molecular Cancer

Objectives Palytoxin (PTX), a marine toxin isolated from the Cnidaria (zooanthid) Palythoa caribaeorum is one of the most potent non-protein substances known. It is a very complex molecule that presents both lipophilic and hydrophilic areas. The effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdb90ba0444b60ab124bbb2bb215593
http://www.molecular-cancer.com/content/12/1/12

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