Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Autor: Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer, René E. M. Toes

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)

Abstract Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modificati

Externí odkaz: https://doaj.org/article/63a2b8cb09d24e27bf69a399f673442e

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Cross-reactivity of anti-modified protein antibodies is also present in predisease and individuals without rheumatoid arthritis.

Autor: Reijm S; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands s.reijm@lumc.nl., Brehler AS; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Rantapää-Dahlqvist S; Department of Public Health and Clinical Medicine/Rheumatology, Umeå Universitet, Umea, Sweden., Kawakami A; Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Maeda T; Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Kawashiri SY; Department of Immunology and Rheumatology Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Tamai M; Department of Immunology and Rheumatology Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., van der Woude D; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2022 Aug 11; Vol. 81 (9), pp. 1332-1334. Date of Electronic Publication: 2022 Aug 11.

Anti-citrullinated protein antibodies dominate the association of long-term outcomes and anti-modified protein antibodies in rheumatoid arthritis.

Autor: van Wesemael TJ; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands., Verstappen M; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands., Knevel R; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands., van der Helm-van Mil AHM; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands., Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands., van der Woude D; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, Netherlands. Electronic address: dvanderwoude@lumc.nl.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2022 May; Vol. 4 (5), pp. e316-e317.

Anti-citrullinated protein antibodies dominate the association of long-term outcomes and anti-modified protein antibodies in rheumatoid arthritis

Autor: Wesemael, T.J. van, Verstappen, M., Knevel, R., Helm-van Mil, A.H.M. van der, Toes, R.E.M., Woude, D. van der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0484ce93d075619d392384cd2c5076
https://hdl.handle.net/1887/3458789