Zobrazeno 1 - 10
of 1 331
pro vyhledávání: '"Anti-fibrotic"'
Autor:
Inge Jacobs, Sara Deleu, Bo-Jun Ke, Jonathan Cremer, Ellen Dilissen, Gert De Hertogh, Tobie Martens, Pieter Vanden Berghe, Gianluca Matteoli, Séverine Vermeire, Christine Breynaert, Tim Vanuytsel, Bram Verstockt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Eosinophils were previously reported to play a role in intestinal inflammation and fibrosis. Whether this is as a bystander or as an active participant is still up for debate. Moreover, data describing a causal relationship between eosinophi
Externí odkaz:
https://doaj.org/article/6512c87b82af4c53b571507dd318e924
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Liver fibrosis is a hallmark of chronic liver disease which could lead to liver cirrhosis or liver cancer. However, there is currently lack of a direct treatment for liver fibrosis. Boiling histotripsy (BH) is an emerging non-invasive high-i
Externí odkaz:
https://doaj.org/article/3f84443f2c1441d1a794867a492895ae
Autor:
Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundIdiopathic pulmonary fibrosis (IPF) is the result of multiple cycles of epithelial cell injury and fibroblast activation; currently, there is no clear etiology. Increasing evidence suggests that protein metabolism and amino acids play a cru
Externí odkaz:
https://doaj.org/article/d91923396dea4d9eac3244d7ab92f79c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116957- (2024)
Duchenne muscular dystrophy (DMD) is the most common muscular disorder affecting children. It affects nearly 1 male birth over 5000. Oxidative stress is a pervasive feature in the pathogenesis of DMD. Recent work shows that the main generators of ROS
Externí odkaz:
https://doaj.org/article/9823b26ffa2a4165994f36199bd3254d
Autor:
Elsayed A. Elmorsy, Sameh Saber, Ahmed Y. Kira, Abdullah Alghasham, Mohamed R. Abdel-Hamed, Maha M. Amer, Enas A. Mohamed, A AlSalloom A., Abdullah S. Alkhamiss, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Abousree T. Ellethy, Hossam A. Elsisi, Mansour Alsharidah, Sahar R. Elghandour, Tayseer Elnawawy, Rasha Abdelhady
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Liver fibrosis is a disease with a great global health and economic burden. Existing data highlights itraconazole (ITRCZ) as a potentially effective anti-fibrotic therapy. However, ITRCZ effect is hindered by several limitations, such as poor solubil
Externí odkaz:
https://doaj.org/article/eb5bfc44fea240ac8fcbac5fbfdb48f7
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e29486- (2024)
Fibrosis, a significant health issue linked to chronic inflammatory diseases, affects various organs and can lead to serious damage and loss of function. Despite the availability of some treatments, their limitations necessitate the development of ne
Externí odkaz:
https://doaj.org/article/9806f0754cc741c58836c5d8e96a42bf
Autor:
Amlan Chakraborty, Keshav Raj Paudel, Chao Wang, Gabriele De Rubis, Dinesh Kumar Chellappan, Philip Michael Hansbro, Chrishan S. Samuel, Kamal Dua
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1104-1108 (2023)
Externí odkaz:
https://doaj.org/article/53c10037cd564641abf92b9bc6c76ce1
Autor:
Irene Mignini, Valentina Blasi, Fabrizio Termite, Giorgio Esposto, Raffaele Borriello, Lucrezia Laterza, Franco Scaldaferri, Maria Elena Ainora, Antonio Gasbarrini, Maria Assunta Zocco
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6326 (2024)
Bowel strictures are well recognized as one of the most severe complications in Crohn’s disease, with variable impacts on the prognosis and often needing surgical or endoscopic treatment. Distinguishing inflammatory strictures from fibrotic ones is
Externí odkaz:
https://doaj.org/article/d0b7053f89924d3f94f54ed61975b32b
Autor:
Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen, Qingran Yan
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized anti-rheumatic disease-modifying drug, which shows drastic inhibition to EGR1 expr
Externí odkaz:
https://doaj.org/article/8dcedb4e508e4234a87abe795a9d4229
Publikováno v:
Xin yixue, Vol 54, Iss 6, Pp 384-387 (2023)
Sarcoidosis is a systemic disease characterized by non-caseous epithelioid cell granuloma，which can involve with multiple organs，especially the lung. Sarcoidosis is characterized by diverse clinical manifestations and high incidence rate. Partial
Externí odkaz:
https://doaj.org/article/2a83a10c5ac24375ac7d804108d36292