Lateral membrane organization as target of an antimicrobial peptidomimetic compound

Publikováno v: Nature Communications. 14(1)

Antimicrobial resistance is one of the leading concerns in medical care. Here we study the mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high speed-atomic force microscopy, molecular dynamics, fluorescence assays,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::2dab365701c9d317f263c1097cdef8ec
https://doi.org/10.1038/s41467-023-39726-5

Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Autor: Elena Azzini, Javad Sharifi-Rad, Ahmet Beyatli, Yasaman Taheri, Hafiz Ansar Rasul Suleria, William N. Setzer, Anuj Kumar, Alfred Maroyi, Prabhakar Semwal, Miquel Martorell, G. A. Seitimova, Sakshi Painuli, Oksana Sytar, Balakyz Yeskaliyeva, Bahare Salehi, Natália Martins

Publikováno v: BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Complementary Medicine and Therapies

Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c76e7770e1cb61be1b55d8533431a56
http://link.springer.com/article/10.1186/s12906-020-03033-z

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Autor: Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e45c56c9b3fcde327e5251318035d4
https://escholarship.org/uc/item/0388t0qm

The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria

Autor: Thomas Vorup-Jensen, Marlene Fredborg, Michael Lykke Hvam, Rikke Louise Meyer, R.A. Murphy, Mihaela Gadjeva, Jens R. Nyengaard, Arne Möller, Stig Hill Christiansen, M. Wang, Sandra M. Skovdal, Kenneth A. Howard, Eskild Petersen, Jane C. Davies, Kristian Juul-Madsen, Uffe B. Skov Sørensen, Esben Axelgaard, Niels Nørskov-Lauritsen

Publikováno v: Hill Christiansen, S, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sørensen, U B S, Möller, A, Nyengaard, J R, Nørskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Christiansen, S H, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sorensen, U B S, Moeller, A, Nyengaard, J R, Norskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports

Classic drug development strategies have failed to meet the urgent clinical needs in treating infections with Gram-negative bacteria. Repurposing drugs can lead to timely availability of new antibiotics, accelerated by existing safety profiles. Glati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99382febee1c7502b41664ee0b7018f
https://doi.org/10.1038/s41598-017-15969-3

Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus

Autor: Françoise Van Bambeke, Paul M. Tulkens, Sandrine Lemaire

Publikováno v: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011)

In contrast to currently marketed fluoroquinolones, which are zwitterionic, delafloxacin is an investigational fluoroquinolone with an anionic character that is highly active against Gram-positive bacteria. We have examined the effect of acidic pH on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8112214dcc534fc3e5621bbe7cab9e
https://doi.org/10.1128/aac.01201-10