Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis

Autor: Thomas Tørring, Jaime Moyano-Villameriel, Malene Wollesen, Thomas B. Poulsen, Christine N. Pedersen, Frederikke D. Andersen, Han Liu, Kristian M. Jacobsen, Peter Nørby, Shaoquan Lin, Esben B. Svenningsen

Publikováno v: Nature Chemistry
Nature chemistry
Lin, S, Liu, H, Svenningsen, E B, Wollesen, M, Jacobsen, K M, Andersen, F D, Moyano-Villameriel, J, Pedersen, C N, Nørby, P, Tørring, T & Poulsen, T B 2021, ' Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis ', Nature Chemistry, vol. 13, no. 1, pp. 47-55 . https://doi.org/10.1038/s41557-020-00601-1

Polyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95445becf1000d7092cfae4f7e688d01
https://doi.org/10.1038/s41557-020-00601-1

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori -Infected Mice

Autor: Angel Lanas, Eliette Touati, Jessica Bueno, Hilde De Reuse, Liliana Rodrigues, J. Castillo, Miriam Alías, José A. Aínsa, Javier Sancho, Adrián Velázquez-Campoy, Alejandro Mahía, Sandra Salillas, Ainhoa Lucía, Carlos Sostres, María D. Díaz-de-Villegas, Juan J. Galano-Frutos, Valérie Michel, José Alberto Carrodeguas

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Helicobacter pylori (Hp) infection is the main cause of peptic ulcer and gastric cancer. Hp eradication rates have fallen due to increasing bacterial resistance to currently used broad-spectrum antimicrobials. We have designed, synthesized, and teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e850d663d7b8057cada3c251140cf5cf
https://hal-pasteur.archives-ouvertes.fr/pasteur-02868148

Studies of a furanoside as antimycobacterial agent loaded into a biodegradable PBAT/sodium caseinate support

Autor: Richard Daniellou, Laurent Legentil, Caroline Nugier-Chauvin, Jean-Luc Audic, Vincent Ferrières

Publikováno v: Carbohydrate Research
Carbohydrate Research, Elsevier, 2011, 346 (12), pp.1541-5. ⟨10.1016/j.carres.2011.04.025⟩
Carbohydrate Research, 2011, 346 (12), pp.1541-5. ⟨10.1016/j.carres.2011.04.025⟩

International audience; An improved synthesis of n-octyl β-D-galactofuranoside was described using micro-wave activation. The resulting alkyl furanoside showed antibacterial activity against Mycobacterium smegmatis, a non-pathogenic model of Mycobac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b96ab96255aab1b774881ca4b551e6
https://pubmed.ncbi.nlm.nih.gov/21592464