Výsledky vyhledávání - "Anthracenes/pharmacology"

Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth

Autor: Roberto Montesano

Publikováno v: Biochemical and Biophysical Research Communications, Vol. 353, No 3 (2007) pp. 817-22

Bone morphogenetic proteins (BMPs) are multifunctional cytokines that regulate key developmental processes, but are also overexpressed in many carcinomas. To assess whether BMPs would influence the three-dimensional architecture of epithelial structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdd5b715a52d99783c7f0307b57e08f
https://doi.org/10.1016/j.bbrc.2006.12.109

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Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation

Autor: Alain Géloën, Jennifer Rieusset, Sandra Pesenti, Bader Zarrouki, Roxane E. Vella, Marie-Agnès Chauvin, Nicolas J. Pillon, Marine L. Croze, Michel Guichardant, Christophe O. Soulage, Laetitia Koppe

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2015, 64 (3), pp.1011-24. ⟨10.2337/db13-1181⟩

International audience; A growing body of evidence suggests that exposure to traffic-related air pollution is a risk factor for type 2 diabetes. Ozone, a major photochemical pollutant in urban areas, is negatively associated with fasting glucose and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6cb4e7ce052da493f4a1dfca70c555
https://hal.archives-ouvertes.fr/hal-01850613

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Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta

Autor: Tanioka, Toshihiro, Tamura, Yoshiaki, Fukaya, Makiko, Shinozaki, Shohei, Mao, Ji, Kim, Minhye, Shimizu, Nobuyuki, Kitamura, Tadahiro, Kaneki, Masao

Publikováno v: The Journal of biological chemistry, 286 (33

Insulin receptor substrate-2 (IRS-2) plays a critical role in the survival and function of pancreatic β-cells. Gene disruption of IRS-2 results in failure of the β-cell compensatory mechanism and diabetes. Nonetheless, the regulation of IRS-2 prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2101::5cd6bd8df62b7b298fb07b06ab18b32b
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/136991

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Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression

Autor: Paolo Pugnale, Eric Féraille, Roberto Montesano, Fabio Carrozzino

Publikováno v: American Journal of Physiology. Cell Physiology, Vol. 297, No 3 (2009) pp. C775-87

Tight junctions (TJs) form a barrier to the paracellular diffusion of ions and solutes across epithelia. Although transmembrane proteins of the claudin family have emerged as critical determinants of TJ permeability, little is known about the signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453f024512e3f78cbb5380fb7b213b92
https://pubmed.ncbi.nlm.nih.gov/19605737

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Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts

Autor: Pierre-André Guerne, Walter Reith, Jean-Michel Dayer, Carlo Chizzolini, Serena Fineschi

Publikováno v: FASEB Journal, Vol. 20, No 3 (2006) pp. 562-564

Tissue fibrosis results when dysregulation of extracellular matrix (ECM) turnover favors deposition of collagen and other ECM proteins over degradation. Fibrosis may then lead to organ dysfunction and pathology as observed in systemic sclerosis (SSc)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27533f83f054ce4111deacabc44d73cf
https://archive-ouverte.unige.ch/unige:11246

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A double-membrane model for urinary bicarbonate secretion

Autor: Renaud Beauwens, Joseph Palmisano, Philip R. Steinmetz, David L. Stetson, Peter Mitchell

Publikováno v: American journal of physiology. Renal physiology. 249 (4

To define the transport pathway for HCO-3 secretion (JHCO3) across the apical and basolateral membranes of turtle bladder, we examined the effects of cAMP, isobutylmethylxanthine (IBMX), the Cl- channel blocker 9-anthroic acid (9-AA), and the disulfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6541a3415504ce30787eac7cf5a46c37
https://doi.org/10.1152/ajprenal.1985.249.4.f546

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