Cigarette Smoking‐Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets

Autor: Curtis Lee Lowery, Clay Elliott, Anthonya Cooper, Coedy Hadden, Roberto N. Sonon, Parastoo Azadi, D. Keith Williams, James D. Marsh, Donna S. Woulfe, Fusun Kilic

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)

BackgroundCigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system–mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimul

Externí odkaz: https://doaj.org/article/30ff2937ed594d27a398794e4f71035d

Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway

Autor: Tariq Fahmi, Drucilla J. Roberts, Alena V. Savenka, Vladimir Lupashin, Coedy Hadden, Sylvie Hauguel-de Mouzon, Anthonya Cooper, Fusun Kilic, Luc Maroteaux

Publikováno v: Journal of Cellular Physiology
Journal of Cellular Physiology, Wiley, 2017, 232 (12), pp.3520-3529. ⟨10.1002/jcp.25812⟩
Journal of Cellular Physiology, 2017, 232 (12), pp.3520-3529. ⟨10.1002/jcp.25812⟩

International audience; Serotonin (5-HT) and its specific transporter, SERT play important roles in pregnancy. Using placentas dissected from 18d gestational SERT-knock out (KO), peripheral 5-HT (TPH1)-KO, and wild-type (WT) mice, we explored the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c14595222cd9fbc4ccc840b2c8523
https://doi.org/10.1002/jcp.25812

Expression of Concern: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta

Autor: Pamela Murphy, Fusun Kilic, Luc Maroteaux, Curtis L. Lowery, Yicong Li, Asli Ahmed, Ruston Koonce, Nafisa K. Dajani, Imelda N. Odibo, Drucilla J. Roberts, Anthonya Cooper

Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. Because of the defect on insulin receptor (IR) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c8ccd02a3cd323c6e54a4dc4c5704
https://europepmc.org/articles/PMC6442031/

Retraction Note: Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability

Autor: Asli Ahmed, Hong Wu, Vladimir Lupashin, Coedy Hadden, Philip R. Mayeux, Fusun Kilic, Yicong Li, Anthonya Cooper

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports

Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates the microvascular permeability during sepsis. The plasma 5-HT levels are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836d30810134233bb85356d977b98aaf
http://link.springer.com/article/10.1038/s41598-019-50843-4

Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability

Autor: Yicong Li, Coedy Hadden, Anthonya Cooper, Asli Ahmed, Hong Wu, Vladimir V. Lupashin, Philip R. Mayeux, Fusun Kilic

Publikováno v: Scientific Reports

Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates the microvascular permeability during sepsis. The plasma 5-HT levels are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8201b454b76d6d5d41f5034d53f5af2a
http://europepmc.org/articles/PMC4783700