Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Anthony Y. H. Lu"'
Autor:
Elana Hummel, Maya Cakmak, Michael Jae-Yoon Chung, Sai Harshita Neti, Anthony Y. H. Lu, Mino Nakura
Publikováno v:
RO-MAN
Concurrency makes robot programming challenging even for professional programmers, yet it is essential for rich, interactive social robot behaviors. Visual programming aims to lower the barrier for robot programming but does not support rich concurre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4369638137304035e60e7f5c545fab12
https://doi.org/10.1109/ro-man47096.2020.9223337
https://doi.org/10.1109/ro-man47096.2020.9223337
Autor:
Wei Tang, Anthony Y H Lu
Publikováno v:
Current Pharmaceutical Design. 15:2170-2183
Pharmacokinetics has been recognized as one of the elements determining the probability of success in pharmaceutical research. As a result, compounds are routinely evaluated in drug discovery for their absorption, distribution, metabolism and elimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9865f45c74886c64261d9cf89cc1fd68
https://doi.org/10.2174/138161209788682451
https://doi.org/10.2174/138161209788682451
Autor:
Anthony Y. H. Lu, Magang Shou
Publikováno v:
Drug Metabolism and Disposition. 37:925-931
Cytochrome P450 (P450) is the superfamily of enzymes responsible for biotransformation of endobiotics and xenobiotics. However, their large isoform multiplicity, inducibility, diverse structure, widespread distribution, polymorphic expression, and br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bdb5734e132a91ed3663127cadb3f9
https://doi.org/10.1124/dmd.108.025718
https://doi.org/10.1124/dmd.108.025718
Publikováno v:
Current Drug Metabolism. 6:503-517
An important role of human cytochrome P450s (P450s) has been well recognized in the area of drug metabolism and pharmacokinetics. It has become possible in recent years to express catalytically active forms of these enzymes in various host systems. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d29fd3208f97dfc85da15575b5caed
https://doi.org/10.2174/138920005774330602
https://doi.org/10.2174/138920005774330602
Autor:
Anthony Y. H. Lu, Qiang Ma
Publikováno v:
Chemical Research in Toxicology. 16:249-260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e9f2b08cd6dd4c959a830fa2ca7ee4
https://doi.org/10.1021/tx0200919
https://doi.org/10.1021/tx0200919
Publikováno v:
Biochemistry. 35:6745-6753
A conserved tyrosine plays a critical role in catalysis by mammalian glutathione S-transferases (GSTs) of the alpha-, mu-, and pi-classes, by forming a hydrogen bond to and stabilizing the thiolate form of glutathione. The hydrogen bonding properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b859a9b8abd8f2e10fbf4c1f6be5381
https://doi.org/10.1021/bi9530346
https://doi.org/10.1021/bi9530346
Publikováno v:
Proceedings of the National Academy of Sciences. 92:1043-1047
NAD(P)H:quinone oxidoreductase (NQOR; EC 1.6.99.2) is a homodimeric enzyme which catalyzes the reduction of quinones, azo dyes, and other electron acceptors by NADPH or NADH. To pursue subunit functional studies, we expressed a wild-type/mutant heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f2e9bf6126de2b7902c4da57e78574
https://doi.org/10.1073/pnas.92.4.1043
https://doi.org/10.1073/pnas.92.4.1043
Autor:
Anthony Y. H. Lu, Qiang Ma
Publikováno v:
Pharmacological reviews. 63(2)
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2e4a24ba7c05fb9b026fc7931f8261
https://pubmed.ncbi.nlm.nih.gov/21436344
https://pubmed.ncbi.nlm.nih.gov/21436344
Autor:
Qiang, Ma, Anthony Y H, Lu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(7)
CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::583bc73fb2e41b627afde505a73b7d05
https://pubmed.ncbi.nlm.nih.gov/17431034
https://pubmed.ncbi.nlm.nih.gov/17431034