Rapid active zone remodeling consolidates presynaptic potentiation

Autor: Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r

Externí odkaz: https://doaj.org/article/9733b2fe50774e4e995b69653b092187

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

Autor: Natalie Blaum, Anthony W. McCarthy, Kristina Ponimaskine, David Schwefel, Monika Berezeckaja, Alexander M. Walter, Mathias A Böhme

Publikováno v: Böhme, M A, McCarthy, A W, Blaum, N, Berezeckaja, M, Ponimaskine, K, Schwefel, D & Walter, A M 2021, ' Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function ', Glia, vol. 69, no. 8, pp. 1897-1915 . https://doi.org/10.1002/glia.24000
Boehme, M, McCarthy, A, Blaum, N, Berezeckaja, M, Ponimaskine, K, Schwefel, D & Walter, A M 2021, ' Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply and is required for motor function ', pp. E310 . https://doi.org/10.1002/glia.24036

Peripheral nerves contain sensory and motor neuron axons coated by glial cells whose interplay ensures function, but molecular details are lacking. SNARE-proteins mediate the exchange and secretion of cargo by fusing vesicles with target organelles,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fc237ed92c18dd2918c2e9aa7533f3
https://pubmed.ncbi.nlm.nih.gov/33811396

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Autor: Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W.B. Götz, Susanne Ditlevsen, Alexander M. Walter

Publikováno v: Grasskamp, A T, Jusyte, M, McCarthy, A W, Götz, T W B, Ditlevsen, S & Walter, A M 2023, ' Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials ', Frontiers in Cellular Neuroscience, vol. 17, 1129417 . https://doi.org/10.3389/fncel.2023.1129417

Synaptic transmission relies on presynaptic neurotransmitter (NT) release from synaptic vesicles (SVs) and on NT detection by postsynaptic receptors. Transmission exists in two principal modes: action-potential (AP) evoked and AP-independent, “spon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1054f2c84fda9009a439f363c9765011
https://doi.org/10.1101/2020.08.28.271742

Rapid active zone remodeling consolidates presynaptic potentiation

Autor: Anthony W. McCarthy, Christine B. Beuschel, Martin Lehmann, Astrid G. Petzoldt, Stefan W. Hell, Sheng Huang, Pragya Goel, Meida Jusyte, Stephan J. Sigrist, Dion Dickman, Andreas T. Grasskamp, Desiree Laber, Ulises Rey, Alexander M. Walter, Fabian Goettfert, David Owald, Pejmun Haghighi, Mathias A. Böhme

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4269dc4a6ddf4bea062253cfd4a33
https://doi.org/10.1038/s41467-019-08977-6

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Autor: Anthony W. McCarthy, Gregor Reither, Alexander M. Walter, Martin Lehmann, Bassam Tawfik, Keimpe D. Wierda, Rainer Müller, Volker Haucke, Paulo S. Pinheiro, Martin Kruse, Bertil Hille, Carsten Schultz, Jens Rettig, Jakob B. Sørensen, André Nadler, Iwona Ziomkiewicz

Publikováno v: eLife
eLife, 6:e30203
eLife, Vol 6 (2017)
Walter, A M, Müller, R, Tawfik, B, Wierda, K D, Pinheiro, P S, Nadler, A, McCarthy, A W, Ziomkiewicz, I, Kruse, M, Reither, G, Rettig, J, Lehmann, M, Haucke, V, Hille, B, Schultz, C & Sorensen, J B 2017, ' Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis ', eLife, vol. 6, e30203 . https://doi.org/10.7554/eLife.30203

Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78220af04bf9bff78eb152aadb485c62
https://pubmed.ncbi.nlm.nih.gov/29068313