Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anthony W Harrington"'
Autor:
Grace Woodruff, Naomi Phillips, Cassiano Carromeu, Oivin Guicherit, Alistair White, McCay Johnson, Fabian Zanella, Blake Anson, Timothy Lovenberg, Pascal Bonaventure, Anthony W Harrington
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240991 (2020)
Human induced Pluripotent Stem Cells (iPSCs) are a powerful tool to dissect the biology of complex human cell types such as those of the central nervous system (CNS). However, robust, high-throughput platforms for reliably measuring activity in human
Externí odkaz:
https://doaj.org/article/35b57f2d9c9348399512c9991766b55f
Autor:
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 688-696 (2017)
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightl
Externí odkaz:
https://doaj.org/article/3133717f13e440569d759f9048cbb811
Autor:
Anthony W. Harrington, Changlu Liu, Naomi Phillips, Diane Nepomuceno, Chester Kuei, Joseph Chang, Weixuan Chen, Steven W. Sutton, Daniel O'Malley, Ly Pham, Xiang Yao, Siquan Sun, Pascal Bonaventure
Background and Purpose: Gpr17 is an orphan receptor involved in the process of myelination due to its ability to inhibit the maturation of oligodendrocyte progenitor cells into myelinating oligodendrocytes. Despite multiple claims that the biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aac7edbc987940525e5d0cff62af2aa
https://doi.org/10.22541/au.165237522.22210672/v1
https://doi.org/10.22541/au.165237522.22210672/v1
Autor:
Weston B. Davini, David S. Bredt, Edward R. Siuda, Shenyan Gu, Brian Lord, Jose A. Matta, Anthony W. Harrington
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 688-696 (2017)
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine. Neuronal nAChRs derive from combinations of α and β subunits, whose assembly is tightl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9b73c13abc43cf6a37782298a1cd74
http://www.sciencedirect.com/science/article/pii/S2211124717304837
http://www.sciencedirect.com/science/article/pii/S2211124717304837
Autor:
Christopher D. Deppmann, Dong Suo, Anthony W. Harrington, Larry S. Zweifel, Stefan Mihalas, Juyeon Park
Publikováno v:
Nature neuroscience
Retrograde communication from axonal targets to neuronal cell bodies is critical for both the development and function of the nervous system. Much progress has been made in recent years linking long-distance, retrograde signaling to a signaling endos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331880e38316d494e945896672fa3a42
https://doi.org/10.1038/nn.3593
https://doi.org/10.1038/nn.3593
Autor:
Anthony W. Harrington, David D. Ginty
Publikováno v:
Nature Reviews Neuroscience. 14:177-187
The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect and respond to injury and aspects of neuronal development, such as axon and dendrite growth, plasticity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148372cd05015c197ea3cfdaa48b5b0c
https://doi.org/10.1038/nrn3253
https://doi.org/10.1038/nrn3253
Autor:
Simon Halegoua, Polyxeni Philippidou, Natalia O. Glebova, Larry S. Zweifel, Coryse St. Hillaire, Anthony W. Harrington, David D. Ginty
Publikováno v:
Cell. 146:421-434
Summary The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuronal survival. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45146f287b6c81ef2165d82e38ec1fc2
https://doi.org/10.1016/j.cell.2011.07.008
https://doi.org/10.1016/j.cell.2011.07.008
Publikováno v:
Journal of Biological Chemistry. 283:24690-24697
p75 and the Nogo receptor form a signaling unit for myelin inhibitory molecules, with p75 being responsible for RhoA activation. Because p75 lacks the GDP/GTP exchange factor domain, it has remained unclear how p75 activates RhoA. Here, we report tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df8c5174bb842410fe90bd71afd8774
https://doi.org/10.1074/jbc.m802188200
https://doi.org/10.1074/jbc.m802188200
Autor:
Jose A. Matta, Weston B. Davini, David S. Bredt, Anthony W. Harrington, Brian Lord, Shenyan Gu, Steven W. Sutton
Publikováno v:
Neuron. 89(5)
Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling improves symptoms in Alzheimer's disease and schizophrenia. The pharmaceutical study of α7 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a196cb363eabef5b0f33178b9e1d5b91
https://pubmed.ncbi.nlm.nih.gov/26875622
https://pubmed.ncbi.nlm.nih.gov/26875622
Autor:
Sung Ok Yoon, R. Lee, Juan Carlos Arévalo, Barbara L. Hempstead, C. Blechschmitt, Michael Meyer, Klaus M. Giehl, Anthony W. Harrington, B. Leiner, K. Mörl
Publikováno v:
Proceedings of the National Academy of Sciences. 101:6226-6230
The unprocessed precursor of the neurotrophin nerve growth factor (NGF), proNGF, has been suggested to be a death-inducing ligand for the neurotrophin receptor p75. Whether proNGF is a true pathophysiological ligand that is secreted, binds p75, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3cf50807f0ae7f5cff5d8dba21eba3
https://doi.org/10.1073/pnas.0305755101
https://doi.org/10.1073/pnas.0305755101