Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anthony Vattay"'
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Additional method details for ATAC-Seq Data Analysis and ChIP-qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667bbae7f1dda626aef222d2078505f7
https://doi.org/10.1158/1535-7163.22519459
https://doi.org/10.1158/1535-7163.22519459
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Table S1 lists biochemical and cellular activity of BRG1/BRM inhibitors. Supplementary Table S2 lists BRM011 and BRM014 activity across cell line panel. Supplementary Table S3 lists cell lines generated for this study. Supplementary Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ff6df114c3445da1491dc2bf68ac80
https://doi.org/10.1158/1535-7163.22519456
https://doi.org/10.1158/1535-7163.22519456
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Figure S1 shows additional shRNA knockdown data in uveal melanoma cell lines. Supplementary Figure S2 shows additional dual BRG1/BRM knockdown data and BRG1 rescue data. Supplementary Figure S3 shows basal SWI/SNF subunit expression, ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54896da058f0b4949ae1ea1abc687f7e
https://doi.org/10.1158/1535-7163.22519462.v1
https://doi.org/10.1158/1535-7163.22519462.v1
Autor:
Matthew D. Shirley, Julie T. Chen, Ailing Li, Anthony Vattay, David A. Ruddy, Anka Bric, Kay X. Xiang, Simon Mathieu, Troy Smith, Julien Papillon, Deborah Castelletti, Rukundo Ntaganda, Kathleen Sprouffske, Hyo-eun C. Bhang, Yun Feng, Dorothee Abramowski, Ali Farsidjani, Audrey Kauffmann, Grainne Kerr, Aurore Desplat, Geoffrey Bushold, Katsumasa Nakajima, Henrik Möbitz, GiNell Elliott, Christopher D. Adair, Zainab Jagani, Florencia Rago
Publikováno v:
Molecular Cancer Therapeutics. 19:2186-2195
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating mutations in the G protein alpha subunits, GNAQ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a4bf4bd6c499cad099714441dcd05
https://doi.org/10.1158/1535-7163.mct-19-1013
https://doi.org/10.1158/1535-7163.mct-19-1013
Autor:
Julien Papillon, Rajeshri Ganesh Karki, Gregg Chenail, Zainab Jagani, Raviraj Kulathila, Xiaoling Xie, Henrik Möbitz, John Cantwell, Tiancen Hu, Xiaoping Zhu, Felipe Kellermann Hurtado, Tamara J. Gilbert, Anthony Vattay, Daniel King, Hyo-eun C. Bhang, Emily A. Costa, Katsumasa Nakajima, Susan E. Hill, Q. Kimberley Yue, Catherine Luu, Rukundo Ntaganda, Christopher D. Adair, Michael Scott Visser, Jonathan E. Hempel, David Farley, Ailing Li, Anka Bric, Simon Mathieu, Troy Smith, Geoffrey Bushold, Eugen Lounkine, Andriana Jouk, Isabel Park, Katarina Vulic, Kay Xiang, Julie Dooley
Publikováno v:
Journal of Medicinal Chemistry. 61:10155-10172
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homologue Brahma-related gene 1 (BRG1), also kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82980a2b96152a3795980e644fee3da5
https://doi.org/10.1021/acs.jmedchem.8b01318
https://doi.org/10.1021/acs.jmedchem.8b01318
Autor:
Miao Dai, Feng He, Michael A Mcewan, Karen Miller-Moslin, Stefan Peukert, Adam Amaral, Rajesh Karki, Rui Zhang, Lei Huangshu, Rishi K. Jain, Luis Llamas, Tao Sheng, Yanhong Li, Jing Yuan, Melissa Matsumoto, Aaron Bourret, Joseph Kelleher, Walter Michael, Arun Ramamurthy, Marion Dorsch, Ribo Guo, Juliet Williams, Anthony Vattay, Yingchuan Sun, Lawrence Blas Perez, Wieslawa Maniara, Naeem Yusuff
Publikováno v:
Journal of Medicinal Chemistry. 52:3954-3968
Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e53718d09193e5265c1163594152d6
https://doi.org/10.1021/jm900309j
https://doi.org/10.1021/jm900309j
Autor:
Karen Miller-Moslin, Bharat Lagu, John Green, Miao Dai, Michael A Mcewan, Wieslawa Maniara, Juliet Williams, Aaron Bourret, Arun Ramamurthy, Rui Zhang, Silvia Buonamici, Jing Yuan, Kate Wang, Yingchuan Sun, Marion Dorsch, Anlai Wang, Adam Amaral, Feng He, Naeem Yusuff, Anthony Vattay, Joseph Kelleher, Ribo Guo, Stefan Peukert
Publikováno v:
ChemMedChem. 8(8)
Inhibition of the Hedgehog (Hh) pathway targeting the Smoothened receptor has proven therapeutic benefit for the treatment of Hh-dependent cancers. Lead optimization provided a novel type of Smoothened inhibitor based on a pyridazine core resulting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa7ddbd58736c8c5587084c227ef3ed
https://pubmed.ncbi.nlm.nih.gov/23821351
https://pubmed.ncbi.nlm.nih.gov/23821351
Autor:
Kimberly J. Briggs, Marion Dorsch, Shifeng Pan, Yung Mae Yao, Sauveur Michel Maira, Dustin L. Anderson, John Green, Ribo Guo, Markus Warmuth, Christoph Lengauer, Stefan Peukert, Qunyan Yu, William R. Sellers, Silvia Buonamici, Juliet Williams, Beatriz Ospina, Anlai Wang, D. Neil Watkins, Carlos Garcia-Echeverria, Xu Wu, John Monahan, Lance Ostrom, Paul Fordjour, Jing Yuan, Kathy Hsiao, Joseph Kelleher, Michael Morrissey, Anthony Vattay
Publikováno v:
Science Translational Medicine. 2
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in medulloblastoma. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for treating this disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aed38000042ae62457b7a3343029c37
https://doi.org/10.1126/scitranslmed.3001599
https://doi.org/10.1126/scitranslmed.3001599
Autor:
Joseph Kelleher, Yan Wang, AnneMarie Culazzo Pferdekamper, Jun Liu, Fangxian Sun, Stephanie Kay Dodd, Melissa Matsumoto, Nathan P. Englund, Xu Wu, Jeffrey Tsao, Juliet Williams, Jing Yuan, Dai Cheng, Yun Jiang, Jiqing Jiang, Anthony Vattay, Wenqi Gao, Tove Tuntland, Markus Warmuth, Yung-mae Yao, Stefan Peukert, Ribo Guo, Yongqin Wan, Wieslawa Maniara, Karen Miller-Moslin, Dong Han, Shifeng Pan, Marion Dorsch
The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ce5eef6382294d82ddf4576370849
https://europepmc.org/articles/PMC4007689/
https://europepmc.org/articles/PMC4007689/
Autor:
Ribo Guo, Andrew Wylie, William R. Sellers, Anka Bric, Vesselina G. Cooke, Joshua M. Korn, Jing Yuan, Ramu Thiruvamoor, Anthony Vattay, Rosemary Barrett, Guiqing Liang, Nicholas Keen, Xin Li
Publikováno v:
Molecular Cancer Therapeutics. 12:C149-C149
GNAQ mutations are early and frequent events in the pathology of Uveal Melanoma. These mutations hyper-activate PLCb-PKC-ERK1/2 signaling resulting in PKC dependence. Targeting GNAQ mutant Uveal Melanoma Cells with the PKC inhibitor AEB071 (Sotrastau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f9c9876d25fab74ce8c234ff837110
https://doi.org/10.1158/1535-7163.targ-13-c149
https://doi.org/10.1158/1535-7163.targ-13-c149