Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anthony V, Azzara"'
Autor:
Joseph A. Daccache, Francis Eng, Lei Cao, Ning Ma, Stephen C. Ward, Thomas Schiano, Mark Miller, Daniel Herron, Anthony V. Azzara, Steven S. Pullen, Paolo Guarnieri, Costica Aloman, Andrea D. Branch
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/dfe5f6ac40824995975fd62165fa8afb
Autor:
Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
Publikováno v:
Journal of Medicinal Chemistry. 64:15549-15581
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clinical compound BMS-986020 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256
https://doi.org/10.1021/acs.jmedchem.1c01256
Autor:
Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14773-14792
MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356
https://doi.org/10.1021/acs.jmedchem.1c01356
Autor:
Ying Wang, Jack Krupinski, Gary G. Cao, Xiaoliang Zhuo, Joseph Carpenter, Erica Cook, Milinda Ziegler, Karen A. Rossi, Anthony V. Azzara, Kathy Mosure, Gang Wu, Matthew G. Soars, Dean A. Wacker, Bruce A. Ellsworth, Doree F. Sitkoff, Tao Wang
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery and preclinical biological evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce42c1d64be61d8389ebf3b9000ba19f
https://doi.org/10.1021/acsmedchemlett.1c00198
https://doi.org/10.1021/acsmedchemlett.1c00198
Autor:
Dong Cheng, Bradley A. Zinker, Yi Luo, Petia Shipkova, Claudia H. De Oliveira, Gopal Krishna, Elizabeth A. Brown, Stephanie L. Boehm, Giridhar S. Tirucherai, Huidong Gu, Zhengping Ma, Ching-Hsuen Chu, Joelle M. Onorato, Lisa M. Kopcho, Ron Ammar, Julia Smith, Pratik Devasthale, R. Michael Lawrence, Steven A. Stryker, Elizabeth A. Dierks, Anthony V. Azzara, Leon Carayannopoulos, Edgar D. Charles, Kimberley A. Lentz, David A. Gordon
Publikováno v:
Cell metabolism. 34(11)
Monoacylglycerol acyltransferase 2 (MGAT2) is an important enzyme highly expressed in the human small intestine and liver for the regulation of triglyceride absorption and homeostasis. We report that treatment with BMS-963272, a potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394387e9e73eae85eafb5bf7ab1908f8
https://pubmed.ncbi.nlm.nih.gov/36323235
https://pubmed.ncbi.nlm.nih.gov/36323235
Autor:
Peter T W, Cheng, Robert F, Kaltenbach, Hao, Zhang, Jun, Shi, Shiwei, Tao, Jun, Li, Lawrence J, Kennedy, Steven J, Walker, Yan, Shi, Ying, Wang, Suresh, Dhanusu, Ramesh, Reddigunta, Selvakumar, Kumaravel, Sutjano, Jusuf, Daniel, Smith, Subramaniam, Krishnananthan, Jianqing, Li, Tao, Wang, Rebekah, Heiry, Chi Shing, Sum, Stephen S, Kalinowski, Chen-Pin, Hung, Ching-Hsuen, Chu, Anthony V, Azzara, Milinda, Ziegler, Lisa, Burns, Bradley A, Zinker, Stephanie, Boehm, Joseph, Taylor, Julia, Sapuppo, Kathy, Mosure, Gerry, Everlof, Victor, Guarino, Lisa, Zhang, Yanou, Yang, Qian, Ruan, Carrie, Xu, Atsu, Apedo, Sarah C, Traeger, Mary Ellen, Cvijic, Kimberley A, Lentz, Giridhar, Tirucherai, Lakshmi, Sivaraman, Jeffrey, Robl, Bruce A, Ellsworth, Glenn, Rosen, David A, Gordon, Matthew G, Soars, Michael, Gill, Brian J, Murphy
Publikováno v:
Journal of medicinal chemistry. 64(21)
The oxycyclohexyl acid BMS-986278 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80069106f38ceb56aa2828cf9bc68357
https://pubmed.ncbi.nlm.nih.gov/34709814
https://pubmed.ncbi.nlm.nih.gov/34709814
Autor:
Cory M. Hogaboam, Chris Kitson, Anthony V. Azzara, Milena S. Espindola, David M. Habiel, Ana Lucia Coelho, Barry R. Stripp
Publikováno v:
Mucosal immunology
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease, with unknown etiopathogenesis and suboptimal therapeutic options. Previous reports have shown that increased T-cell numbers and CD28null phenotype is predictive of prognosis in IPF, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294d9dc6e20197cfe08888fe835216da
http://europepmc.org/articles/PMC6301115
http://europepmc.org/articles/PMC6301115
Autor:
Mary Jane Cullen, Qian Xiang, Jeffrey A. Robl, Philip M. Sher, Brian J. Murphy, Keith J. Miller, Timothy M. Harper, Andrew Alt, Emily Luk, Sarah E. Malmstrom, Dean A. Wacker, Ginger Wu, Kimberly A. Foster, John M. Fevig, Joseph Carpenter, Robert L. Bertekap, Mary F. Grubb, Ying Wang, Karen A. Rossi, Gang Wu, Christian L. Morales, Jianxin Feng, Xiang Yang Ye, Anthony V. Azzara, Matthias Broekema
Publikováno v:
Journal of Medicinal Chemistry. 60:6166-6190
Agonism of the 5-HT2C receptor represents one of the most well-studied and clinically proven mechanisms for pharmacological weight reduction. Selectivity over the closely related 5-HT2A and 5-HT2B receptors is critical as their activation has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab408370d6568ec38a8faeab8daced5
https://doi.org/10.1021/acs.jmedchem.7b00385
https://doi.org/10.1021/acs.jmedchem.7b00385
Autor:
Michael Gill, Matt Soars, Robert F. Kaltenbach, Mosure Kathy, Peter T. W. Cheng, Anthony V. Azzara, Stephen S. Kalinowski, Shiwei Tao, Chen-Pin Hung, Larry Kennedy, Yan Shi, Lisa Burns, Julia Sapuppo, Tao Wang, David A. Gordon, Roble Jeffrey, Cvijic Mary-Ellen, Hao Zhang, Ching-Hsuen Chu, Reddigunta Ramesh Babu, Jun Shi, Bruce A. Ellsworth, Jun Li, Bradley A. Zinker, Brian J. Murphy, Dhanusu Suresh, Joseph R. Taylor, Ying Wang, Chi-Shing Sum, Ziegler Milinda, Rebekah Heiry, Steve Walker, Stephanie Boehm
Publikováno v:
Idiopathic interstitial pneumonias.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrosing lung disease with limited approved treatment options. The bioactive lysophospholipid lysophosphatidic acid (LPA) and the LPA1 receptor have been implicated in the etiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b54aea41cff0b233b97a0c88ca4d9ae
https://doi.org/10.1183/13993003.congress-2019.pa5383
https://doi.org/10.1183/13993003.congress-2019.pa5383
Autor:
Jeffrey A. Robl, Michael Thomas, Mary Ann Pelleymounter, Brian Gemzik, Anthony V. Azzara, Brian J. Murphy, Sharon N. Bisaha, Helen E. Godonis, Daniel Longhi, Neil Flynn, William N. Washburn, Kenneth W. Rohrbach, Khehyong Ngu, Saleem Ahmad, Susan Harvey, Christine Huang, Evan B. Janovitz, Andres S. Hernandez, James Devenny, Hongwei Zhang, Lisa Zhang, Susan Glick, Suzanne Rooney, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 59:8848-8858
The potent MCHR1 in vitro and in vivo antagonist activity of a series of cyclic tertiary alcohols derived from compound 2b is described. Subsequent pharmacokinetic and pharmacodynamic studies identified BMS-814580 (compound 10) as a highly efficaciou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b952b4585a825fd9a757591676fa67d8
https://doi.org/10.1021/acs.jmedchem.6b00676
https://doi.org/10.1021/acs.jmedchem.6b00676