Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Anthony Traboulsee"'
Autor:
Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Guenette, Shannon Kolind, Larry Lynd, Ruth Ann Marrie, Luanne M. Metz, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Anthony Traboulsee, Voon Wee Yong, Scott B. Patten
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Disease progression is observed across the spectrum of people with multiple sclerosis (MS) and identification of effective treatment strategies to halt progression remains one of the greatest unmet clinical needs. Objectives: The Canadian
Externí odkaz:
https://doaj.org/article/20a19b62873a48c5bfdb5748cc4d63f4
Autor:
Alasdair J. Coles, Anat Achiron, Anthony Traboulsee, Barry A. Singer, Carlo Pozzilli, Celia Oreja-Guevara, Gavin Giovannoni, Giancarlo Comi, Mark S. Freedman, Tjalf Ziemssen, Debora Shiota, Andreea M. Rawlings, Alana T. Wong, Magdalena Chirieac, Xavier Montalban
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background and objectives: Alemtuzumab demonstrated superior efficacy versus subcutaneous interferon (IFN) beta-1a in participants with relapsing-remitting multiple sclerosis in the 2-year CARE-MS I and II trials. Efficacy was maintained in the 4-yea
Externí odkaz:
https://doaj.org/article/d1ccbb1ea3314b49a9e39f7237862350
Autor:
Maryam Tayyab, Luanne M. Metz, David K.B. Li, Shannon Kolind, Robert Carruthers, Anthony Traboulsee, Roger C. Tam
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionMachine learning (ML) has great potential for using health data to predict clinical outcomes in individual patients. Missing data are a common challenge in training ML algorithms, such as when subjects withdraw from a clinical study, leav
Externí odkaz:
https://doaj.org/article/91aced3148274eb3aa8d5074ee234ee2
Autor:
Jeffrey L. Bennett, Kazuo Fujihara, Ho Jin Kim, Romain Marignier, Kevin C. O'Connor, Robert C. Sergott, Anthony Traboulsee, Heinz Wiendl, Jens Wuerfel, Scott S. Zamvil, Veronica G. Anania, Regine Buffels, Thomas Künzel, Annemarie N. Lekkerkerker, Siân Lennon-Chrimes, Sean J. Pittock
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that produces acute, unpredictable relapses causing cumulative neurological disability. Satralizumab, a humanized, monoclonal recycli
Externí odkaz:
https://doaj.org/article/65073f7848d74c30812b90f40057ec13
Autor:
Mariya V. Cherkasova, Jessie F. Fu, Michael Jarrett, Poljanka Johnson, Shawna Abel, Roger Tam, Alexander Rauscher, Vesna Sossi, Shannon Kolind, David K. B. Li, A. Dessa Sadovnick, Lindsay Machan, J. Marc Girard, Francois Emond, Reza Vosoughi, Anthony Traboulsee, A. Jon Stoessl
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Despite significant insights into the neural mechanisms of acute placebo responses, less is known about longer-term placebo responses, such as those seen in clinical trials, or their interactions with brain disease. We examined brain correla
Externí odkaz:
https://doaj.org/article/30c8b9aed02c4603971a3aaa47f1c6d6
Autor:
Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Guenette, Shannon Kolind, Larry Lynd, Ruth Ann Marrie, Luanne M. Metz, Scott B. Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Anthony Traboulsee, V. Wee Yong
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-19 (2021)
Abstract Background Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (MS). Although there are a handful of disease-modifying treatments approved for use in progressive phenotypes of MS, there are
Externí odkaz:
https://doaj.org/article/eb244b7ca06b45aca81b35c146d52676
Autor:
Adam V. Dvorak, Emil Ljungberg, Irene M. Vavasour, Lisa Eunyoung Lee, Shawna Abel, David K. B. Li, Anthony Traboulsee, Alex L. MacKay, Shannon H. Kolind
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviate
Externí odkaz:
https://doaj.org/article/72b25060dfcd4ad49c4b222ee0d958db
Autor:
Adam V. Dvorak, Taylor Swift-LaPointe, Irene M. Vavasour, Lisa Eunyoung Lee, Shawna Abel, Bretta Russell-Schulz, Carina Graf, Anika Wurl, Hanwen Liu, Cornelia Laule, David K. B. Li, Anthony Traboulsee, Roger Tam, Lara A. Boyd, Alex L. MacKay, Shannon H. Kolind
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We
Externí odkaz:
https://doaj.org/article/1b6a4ddc94404a0f90b8c1513016139e
Myelin water imaging in relapsing multiple sclerosis treated with ocrelizumab and interferon beta-1a
Autor:
Shannon Kolind, Shawna Abel, Carolyn Taylor, Roger Tam, Cornelia Laule, David K.B. Li, Hideki Garren, Laura Gaetano, Corrado Bernasconi, David Clayton, Irene Vavasour, Anthony Traboulsee
Publikováno v:
NeuroImage: Clinical, Vol 35, Iss , Pp 103109- (2022)
Background: Myelin water imaging is a magnetic resonance imaging (MRI) technique that quantifies myelin damage and repair in multiple sclerosis (MS) via the myelin water fraction (MWF). Objective: In this substudy of a phase 3 therapeutic trial, OPER
Externí odkaz:
https://doaj.org/article/be50f8ccff20491dac691d5ad23af4ff
Autor:
Nick Bansback, Judy A. Chiu, Robert Carruthers, Rebecca Metcalfe, Emmanuelle Lapointe, Alice Schabas, Marilyn Lenzen, Larry D. Lynd, Anthony Traboulsee
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Multiple sclerosis (MS) patients often struggle with treatment decisions, in part due to the increasing number of approved disease modifying therapies, each with different characteristics, and also since physicians can struggle to
Externí odkaz:
https://doaj.org/article/dcb96af4ad364376b44b9e9b80c8f480