Výsledky vyhledávání - "Anthony T Trinh"

Is Tranexamic Acid Associated With Mortality or Multiple Organ Failure Following Severe Injury?

Autor: Justin E. Richards, Ken Koerner, Richard D. Betzold, Caroline S. Schlee, Thomas E. Grissom, Rosemary A. Kozar, Benjamin T Fedeles, Jonathan J. Morrison, Jonathan H. Chow, Thomas M. Scalea, Anthony T Trinh, Corinne Renner

Publikováno v: Shock. 55:55-60

BACKGROUND Tranexamic acid (TXA) administration is recommended in severely injured trauma patients. We examined TXA administration, admission fibrinolysis phenotypes, and clinical outcomes following traumatic injury and hypothesized that TXA was asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd498f31873cb74efd09613c1df183a8
https://doi.org/10.1097/shk.0000000000001608

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Thromboelastography Reaction-Time Thresholds for Optimal Prediction of Coagulation Factor Deficiency in Trauma

Autor: Thomas M. Scalea, Michael A. Mazzeffi, Benjamin T Fedeles, Kenichi A. Tanaka, Jonathan J. Morrison, Corinne Renner, Anthony T Trinh, Jonathan H. Chow, Peter Rock, Justin E. Richards, Caroline S. Schlee

Publikováno v: Journal of the American College of Surgeons. 230:798-808

Background Coagulopathy is common in multitrauma patients and repletion of procoagulant factor deficiency with fresh frozen plasma (FFP) improves hemostasis. Optimal kaolin-thromboelastography thresholds for FFP transfusion in trauma patients have no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2192b05d276a85c58c5fae3b7ae7dbf
https://doi.org/10.1016/j.jamcollsurg.2020.01.033

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Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism

Autor: Anthony T. Trinh, Michele Campaigne Larsen, Pierre R. Bushel, Colin R. Jefcoate, Randal S. Tibbetts, Sang Hwa Kim, Adam S. Mastrocola

Publikováno v: Nucleic Acids Research

cAMP response element binding protein (CREB) is a key regulator of glucose metabolism and synaptic plasticity that is canonically regulated through recruitment of transcriptional coactivators. Here we show that phosphorylation of CREB on a conserved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7847472c3259340b82ce71acf9ae2edb
http://europepmc.org/articles/PMC5175338

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The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

Autor: Anthony T. Trinh, Adam S. Mastrocola, Sang Hwa Kim, Lance A. Rodenkirch, Randal S. Tibbetts

Publikováno v: Journal of Biological Chemistry. 288:24731-24741

The list of factors that participate in the DNA damage response to maintain genomic stability has expanded significantly to include a role for proteins involved in RNA processing. Here, we provide evidence that the RNA-binding protein fused in sarcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6954bd23184cceba23ed8b3a8fb95962
https://doi.org/10.1074/jbc.m113.497974

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Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies

Autor: Gerald E. Dodson, Anthony T. Trinh, Yuling Shi, Naval P. Shanware, Partha S. Mukhopadhyay, Randal S. Tibbetts

Publikováno v: Journal of Biological Chemistry. 282:9236-9243

The functionally related ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) protein kinases are critical regulators of DNA damage responses in mammalian cells. ATM and ATR share highly overlapping substrate specificities and show a strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a939c51270df7da6585ab07bd2bde19
https://doi.org/10.1074/jbc.m609256200

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Coregulated Ataxia Telangiectasia-mutated and Casein Kinase Sites Modulate cAMP-response Element-binding Protein-Coactivator Interactions in Response to DNA Damage

Autor: Anthony T. Trinh, Leah M. Williams, Randal S. Tibbetts, Naval P. Shanware

Publikováno v: Journal of Biological Chemistry. 282:6283-6291

The cyclic AMP-response element-binding protein (CREB) is a bZIP family transcription factor implicated as an oncoprotein and neuron survival factor. CREB is activated in response to cellular stimuli, including cAMP and Ca(2+), via phosphorylation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3002ba41d00df508f060f333d15831a7
https://doi.org/10.1074/jbc.m610674200

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Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia

Autor: David A. Wassarman, Gerald E. Dodson, Rebeccah J. Katzenberger, Stacey A. Rimkus, Anthony T. Trinh, Randal S. Tibbetts

Publikováno v: Genesdevelopment. 22(9)

Mutations in ATM (Ataxia telangiectasia mutated) result in Ataxia telangiectasia (A-T), a disorder characterized by progressive neurodegeneration. Despite advances in understanding how ATM signals cell cycle arrest, DNA repair, and apoptosis in respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a2f3d93fcb2864c922651e79408eed
https://pubmed.ncbi.nlm.nih.gov/18408079

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ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells

Autor: Anthony T. Trinh, Randal S. Tibbetts, Gerald E. Dodson, Joel R. Puchalski, Sujatha Kumar

Publikováno v: Cell cycle (Georgetown, Tex.). 4(11)

Hydroxyurea (HU) is a competitive inhibitor of ribonucleotide reductase that is used for the treatment of myeloproliferative disorders. HU inhibits DNA replication and induces apoptosis in a cell type-dependent manner, yet the relevant pathways that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6441a6b2cb53965788e739eb4aa63352
https://pubmed.ncbi.nlm.nih.gov/16258278

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