Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anthony Simon Lynch"'
Autor:
Zhijun Zhuang, Dawei Wan, Jun Ding, Shijie He, Qian Zhang, Xiaomei Wang, Ying Yuan, Yu Lu, Charles Z. Ding, Anthony Simon Lynch, Anna M. Upton, Christopher B. Cooper, William A. Denny, Zhenkun Ma
Publikováno v:
Molecules, Vol 25, Iss 10, p 2431 (2020)
The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades. Pretomanid, a bicyclic 4-nitroimidazole
Externí odkaz:
https://doaj.org/article/acfd95b2677a413b8afef3c83bde534f
Autor:
Peter T. Buckley, Rita Chan, Jeffrey Fernandez, Jinquan Luo, Keenan A. Lacey, Ashley L. DuMont, Aidan O’Malley, Randall J. Brezski, Songmao Zheng, Thomas Malia, Brian Whitaker, Adam Zwolak, Angela Payne, Desmond Clark, Martin Sigg, Eilyn R. Lacy, Anna Kornilova, Debra Kwok, Steve McCarthy, Bingyuan Wu, Brian Morrow, Jennifer Nemeth-Seay, Ted Petley, Sam Wu, William R. Strohl, Anthony Simon Lynch, Victor J. Torres
Publikováno v:
Cell Host & Microbe. 31:751-765.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4756f7a8083a9d7782669668c12b6439
https://doi.org/10.1016/j.chom.2023.04.004
https://doi.org/10.1016/j.chom.2023.04.004
Autor:
Yu Lu, Zhuang Zhijun, Charles Z. Ding, Anthony Simon Lynch, Christopher B. Cooper, Wang Xiaomei, Ding Jun, William A. Denny, Zhenkun Ma, Ying Yuan, Wan Dawei, Qian Zhang, Anna M. Upton, Shijie He
Publikováno v:
Molecules
Molecules, Vol 25, Iss 2431, p 2431 (2020)
Volume 25
Issue 10
Molecules, Vol 25, Iss 2431, p 2431 (2020)
Volume 25
Issue 10
The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades. Pretomanid, a bicyclic 4-nitroimidazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cabc0505ac0c053778aaeaf3306f0ad
http://europepmc.org/articles/PMC7288012
http://europepmc.org/articles/PMC7288012
Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus
Autor:
Jeffrey Fernandez, Anthony Simon Lynch, Rita Chan, William R. Strohl, Victor J. Torres, Angela Payne, William E. Sause, Aidan O’Malley, Ashira Lubkin, Brian Whitaker, Kristina M. Boguslawski, Francis Alonzo, Peter T. Buckley
Publikováno v:
Science Translational Medicine. 11
A key aspect underlying the severity of infections caused by Staphylococcus aureus is the abundance of virulence factors that the pathogen uses to thwart critical components of the human immune response. One such mechanism involves the destruction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85355373f693d9d3042f20dfa7a0515
https://doi.org/10.1126/scitranslmed.aat0882
https://doi.org/10.1126/scitranslmed.aat0882
Autor:
Rita Chan, Brian J. Morrow, William E. Sause, Jeffrey Fernandez, Anthony Simon Lynch, Aidan O’Malley, Richard Copin, Bo Shopsin, Victor J. Torres, Peter T. Buckley
Staphylococcus aureus is a major human pathogen that imposes a great burden on the health care system. In the development of antistaphylococcal modalities intended to reduce the burden of staphylococcal disease, it is imperative to select appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d817950f1050b2ecf058e12e2eed584
https://europepmc.org/articles/PMC5686614/
https://europepmc.org/articles/PMC5686614/
Autor:
Jason Aligo, Bo Shopsin, Ashira Lubkin, Matthew D. Keller, Rita Chan, Anthony Simon Lynch, Victor J. Torres, Maryaline Coffre, Daniel Weinstock, Michael Sugiyama, Francis Alonzo rd, Sergei B. Koralov, Eric Chen, Sofia Bajwa, Ken Cadwell, Nikollaq Vozhilla, Johnny Su, G. Scott Worthen, Changsen Wang, Sang Yong Kim, Peter T. Buckley, Natasha M. Girgis, P'ng Loke, Warren L. Lee, Kamal M. Khanna, Patricia Martin, Marilyn T. Vasquez, Cynthia A. Loomis, Stephen T. Yeung, Aidan O’Malley, Tamara Reyes-Robles
Publikováno v:
Cell Host & Microbe. 25:463-470.e9
Summary The pathogenesis of Staphylococcus aureus is thought to depend on the production of pore-forming leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin ED (LukED) and γ-Hemolysin AB (HlgAB), are necessary and suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24125441d0686ec448dd520e79f84f46
https://doi.org/10.1016/j.chom.2019.01.015
https://doi.org/10.1016/j.chom.2019.01.015
Autor:
Zhenkun Ma, Anthony Simon Lynch
Publikováno v:
Journal of medicinal chemistry. 59(14)
The clinical management of prosthetic joint infections and other persistent bacterial infections represents a major unmet medical need. The rifamycins are one of the most potent antibiotic classes against persistent bacterial infections, but bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9fb9fd4d32eff3d46ca77a2a58923a
https://pubmed.ncbi.nlm.nih.gov/27336583
https://pubmed.ncbi.nlm.nih.gov/27336583
Publikováno v:
Journal of chemotherapy (Florence, Italy). 25(3)
Carbapenem- and fluoroquinolone-non-susceptible Acinetobacter baumannii were obtained from four nosocomial pneumonia patients who were clinically cured following combination therapy with doripenem/levofloxacin or ciprofloxacin. In vitro synergy of do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a594141ce7e1f6e50aa096d137e9964
https://pubmed.ncbi.nlm.nih.gov/23783138
https://pubmed.ncbi.nlm.nih.gov/23783138
Autor:
Eric D. Roche, Dalai Yan, Eric J. Bonventre, Anthony Simon Lynch, Timothy B Doyle, Daniel Denton, Gregory T. Robertson, Keith D. Combrink, Katrina Chapo, Susan Harran, Zhenkun Ma
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
A novel series of 3-morpholino rifamycins in which the C25 acetate group was replaced by a carbamate group were prepared and found to exhibit significantly improved antimicrobial activity than rifampin against Mycobacterium smegmatis. Further charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9591c1db99dba907e8cdc77e9f9a953
https://pubmed.ncbi.nlm.nih.gov/17070048
https://pubmed.ncbi.nlm.nih.gov/17070048