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of 3
pro vyhledávání: '"Anthony Sampognaro"'
Autor:
George B. Mullen, Robert A. Mack, Anthony Sampognaro, John Macor, Patrick Verhoest, Bruce Shepardson
Publikováno v:
The Journal of Organic Chemistry. 69:6493-6495
A direct, short chiral synthesis of the selective alpha7 nicotinic receptor agonist (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one] (AR-R17779) is presented. The key step utilized attack of the dianion of the (R)-HYTRA ester [(R)-(+)-2-hy
Publikováno v:
Organic Syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7db611014d28dc1db7f4acb0f8945e7
https://doi.org/10.1002/0471264180.os077.05
https://doi.org/10.1002/0471264180.os077.05
Autor:
James J. Napier, Jack Gordon, Eifion Phillips, John Zongrone, David Gurley, Yanyi Zhu, Thomas DeCory, James T. Loch, Ronald Griffith, Alexander Kover, Michael Balestra, Anthony Sampognaro, George B. Mullen, and Alan Rosen, Patrick Verhoest, James Blosser, Robert J. Murray, Anthony Machulskis, Gregory Hale, Robert A. Mack, John Macor, Ed Wu
Publikováno v:
Journal of medicinal chemistry. 43(22)
Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel receptor superfamily and may play important roles in modulating neurotransmission, cognition, sensory gating, and anxiety. Because of its distribution and abundanc