Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anthony S. Piro"'
Autor:
Kristin M. Kohler, Miriam Kutsch, Anthony S. Piro, Graham D. Wallace, Jörn Coers, Matthew F. Barber
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Cell-autonomous immunity relies on the rapid detection of invasive pathogens by host proteins. Guanylate binding proteins (GBPs) have emerged as key mediators of vertebrate immune defense through their ability to recognize a diverse array of
Externí odkaz:
https://doaj.org/article/721fbbdb05764fda8e3d02eb4fe03d8b
Autor:
Anthony S. Piro, Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, Jörn Coers
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the h
Externí odkaz:
https://doaj.org/article/51771ab8e9bf43aaa2843d2a7d4c7174
Autor:
Arun K. Haldar, Anthony S. Piro, Ryan Finethy, Scott T. Espenschied, Hannah E. Brown, Amanda M. Giebel, Eva-Maria Frickel, David E. Nelson, Jörn Coers
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT The cytokine gamma interferon (IFN-γ) induces cell-autonomous immunity to combat infections with intracellular pathogens, such as the bacterium Chlamydia trachomatis. The present study demonstrates that IFN-γ-primed human cells ubiquitinat
Externí odkaz:
https://doaj.org/article/c618d4016fa540369c0b58079c401e97
Autor:
Mary S. Dickinson, Miriam Kutsch, Linda Sistemich, Dulcemaria Hernandez, Anthony S. Piro, David Needham, Cammie F. Lesser, Christian Herrmann, Jörn Coers
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host defense against gram-negative cytosolic bacteria in part through the induction of an inflammatory cell death pathway called pyroptosis. To activate pyroptosis, GBPs
Autor:
Mary S. Dickinson, Miriam Kutsch, Linda Sistemich, Dulcemaria Hernandez, Anthony S. Piro, David Needham, Cammie F. Lesser, Christian Herrmann, Jörn Coers
Sensing and killing of intracellular bacterial pathogens are important features of cell-autonomous immunity. The cytokine gamma-interferon (IFNγ) enhances cell-autonomous immunity through upregulation of interferon stimulated genes such as guanylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf368729eb13d0dd541948f3f90efc6
https://doi.org/10.1101/2022.10.05.511023
https://doi.org/10.1101/2022.10.05.511023
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86684 (2014)
Cell-autonomous immunity to the bacterial pathogen Chlamydia trachomatis and the protozoan pathogen Toxoplasma gondii is controlled by two families of Interferon (IFN)-inducible GTPases: Immunity Related GTPases (IRGs) and Guanylate binding proteins
Externí odkaz:
https://doaj.org/article/1a759a43accc4ee5a2ed6d9d843cc547
Autor:
Arun K Haldar, Hector A Saka, Anthony S Piro, Joe Dan Dunn, Stanley C Henry, Gregory A Taylor, Eva M Frickel, Raphael H Valdivia, Jörn Coers
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003414 (2013)
Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit
Externí odkaz:
https://doaj.org/article/d850e28d862a44b7a4c21959a7baf791
Autor:
Jörn Coers, Matthew F. Barber, Graham D. Wallace, Kristin M. Kohler, Anthony S. Piro, Miriam Kutsch
Publikováno v:
mBio
mBio, Vol 11, Iss 3 (2020)
mBio, Vol 11, Iss 3, p e00340-20 (2020)
mBio, Vol 11, Iss 3 (2020)
mBio, Vol 11, Iss 3, p e00340-20 (2020)
Many infectious diseases are caused by microbes that enter and survive within host cells. Guanylate binding proteins (GBPs) are a group of immune proteins which recognize and inhibit a variety of intracellular pathogenic microbes. We discovered that
Autor:
Nichole Orench-Rivera, Miriam Kutsch, Gregory A. Taylor, Seungmin Hwang, Ryan Finethy, Anthony S. Piro, Jennifer Martinez, Sarah Luoma, Arun K. Haldar, Jacob Dockterman, Graham D. Wallace, Meta J. Kuehn, Jörn Coers
Publikováno v:
EMBO Rep
Inflammation associated with gram-negative bacterial infections is often instigated by the bacterial cell wall component lipopolysaccharide (LPS). LPS-induced inflammation and resulting life-threatening sepsis are mediated by the two distinct LPS rec
Autor:
Arun K. Haldar, Seungmin Hwang, Jacob Dockterman, Gregory A. Taylor, Ryan Finethy, Anthony S. Piro, Graham D. Wallace, Miriam Kutsch, Meta J. Kuehn, Sarah Luoma, Jennifer Martinez, Nichole Orench-Rivera, Jörn Coers
Inflammation associated with gram-negative bacterial infections is often instigated by the bacterial cell wall component lipopolysaccharide (LPS). LPS-induced inflammation and resulting life-threatening sepsis are mediated by the two distinct LPS rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6bb6465931ca1fedb488a20934f6df