Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Anthony S, Don"'
Autor:
Michael Allwright, Boris Guennewig, Anna E. Hoffmann, Cathrin Rohleder, Beverly Jieu, Long H. Chung, Yingxin C. Jiang, Bruno F. Lemos Wimmer, Yanfei Qi, Anthony S. Don, F. Markus Leweke, Timothy A. Couttas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The analysis of ceramide (Cer) and sphingomyelin (SM) lipid species using liquid chromatography–tandem mass spectrometry (LC–MS/MS) continues to present challenges as their precursor mass and fragmentation can correspond to multiple mole
Externí odkaz:
https://doaj.org/article/62a64d28e2854c19adb906f91c01ad03
Autor:
Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia
Externí odkaz:
https://doaj.org/article/ec7ffc28bc054f9fa80acef9dc34dab3
Autor:
Alexis Diaz-Vegas, Søren Madsen, Kristen C Cooke, Luke Carroll, Jasmine XY Khor, Nigel Turner, Xin Y Lim, Miro A Astore, Jonathan C Morris, Anthony S Don, Amanda Garfield, Simona Zarini, Karin A Zemski Berry, Andrew P Ryan, Bryan C Bergman, Joseph T Brozinick, David E James, James G Burchfield
Publikováno v:
eLife, Vol 12 (2023)
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly understood
Externí odkaz:
https://doaj.org/article/d4808a63f21b4fbe996fd89139b71d2a
Autor:
Oana C. Marian, Jonathan D. Teo, Jun Yup Lee, Huitong Song, John B. Kwok, Ramon Landin-Romero, Glenda Halliday, Anthony S. Don
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration in FTD with GRN
Externí odkaz:
https://doaj.org/article/c003499d1d084b07b4a2ed66739b76a5
Autor:
Jun Yup Lee, Dylan J. Harney, Jonathan D. Teo, John B. Kwok, Greg T. Sutherland, Mark Larance, Anthony S. Don
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f63074ce0a434945aecfe0f702fa9d07
Autor:
Xin Tracy Liu, Long Hoa Chung, Da Liu, Jinbiao Chen, Yu Huang, Jonathan D. Teo, Xingxing Daisy Han, Yinan Zhao, Fiona H. X. Guan, Collin Tran, Jun Yup Lee, Timothy A. Couttas, Ken Liu, Geoffery W. McCaughan, Mark D. Gorrell, Anthony S. Don, Shubiao Zhang, Yanfei Qi
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading cause of cancer-associated death worldwide. With the increasing prevalence of metabolic conditions, non-alcoholic fatty liver disease (NAFLD) is emerg
Externí odkaz:
https://doaj.org/article/7334783c3e6f40f3a030ad5e6b012c91
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N. Keenan, Paula M. Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B. Schittenhelm, Anthony S. Don, Andrew Ryan, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Benjamin L. Parker, Matthew J. Watt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic ly
Externí odkaz:
https://doaj.org/article/0e3d36630f204b8aa3e526d0e0913eb1
Autor:
Benita C. Y. Tse, Angela L. Ferguson, Yen Chin Koay, Georges E. Grau, Anthony S. Don, Scott N. Byrne
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The ability of ultraviolet radiation to suppress the immune system is thought to be central to both its beneficial (protection from autoimmunity) and detrimental (carcinogenic) effects. Previous work revealed a key role for lipids particularly platel
Externí odkaz:
https://doaj.org/article/439c0caa92d54bf7aa7933e19b9447de
Autor:
I Gusti Md Gde Surya C. Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S. Don, George Qian Li, Jane R. Hanrahan, Yanfei Qi
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time with androgen deprivation therapy, 20% of prostate cancers progress to a castration-resist
Externí odkaz:
https://doaj.org/article/9492847f85534f5abe82d4780ead5644
Autor:
Anne-Marie Lemay, Olivier Courtemanche, Timothy A. Couttas, Giuleta Jamsari, Andréanne Gagné, Yohan Bossé, Philippe Joubert, Anthony S. Don, David Marsolais
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1776-1786 (2019)
Lung cancer causes more deaths than any other cancer. Sphingolipids encompass metabolically interconnected species whose balance has pivotal effects on proliferation, migration, and apoptosis. In this study, we paralleled quantification of sphingolip
Externí odkaz:
https://doaj.org/article/f8012d49b09c43ba97328d687a50b9a0