Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Anthony R. White"'
Autor:
Joanna M. Wasielewska, Juliana C. S. Chaves, Mauricio Castro Cabral-da-Silva, Martina Pecoraro, Stephani J. Viljoen, Tam Hong Nguyen, Vincenzo La Bella, Lotta E. Oikari, Lezanne Ooi, Anthony R. White
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with minimally effective treatment options. An important hurdle in ALS drug development is the non-invasive therapeutic access to the motor co
Externí odkaz:
https://doaj.org/article/8207c90e135c40859406d7de78f6d21d
Autor:
James B. W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Stephen W. Mercer, Bence Paul, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Dominic J. Hare, Blaine R. Roberts, Peter J. Crouch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The copper compound CuII(atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII(atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity is asc
Externí odkaz:
https://doaj.org/article/236516f7a4ca40819c0aeb1e8d9cbdfc
Autor:
Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuro
Externí odkaz:
https://doaj.org/article/8e03f6f959cc4bfcbde5fc381b09f063
Autor:
Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing ne
Externí odkaz:
https://doaj.org/article/c1c1ef71cd304efcb8d9a959888a9cd7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Microglia play crucial roles in immune responses and contribute to fundamental biological processes within the central nervous system (CNS). In neurodegenerative diseases, microglia undergo functional changes and can have both protective and pathogen
Externí odkaz:
https://doaj.org/article/cce4b4ffc8aa4e5581eefb2ec4e26f4b
Autor:
Carla Cuní‑López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ba8db64ecefb4048919a35aa4f0c3af1
Autor:
Hazel Quek, Carla Cuní-López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Tara L. Roberts, Yi Chieh Lim, Lotta E. Oikari, Vincenzo La Bella, Anthony R. White
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflammation mediated by microglia contributes t
Externí odkaz:
https://doaj.org/article/7daea003c67c4e248bf5ed9070b7e5d3
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101747- (2022)
Summary: Microglia are implicated in most neurodegenerative diseases. Here, we present a robust and efficient protocol to differentiate monocyte-derived microglia-like cells (MDMi) from whole blood. The protocol consists of three parts. The first par
Externí odkaz:
https://doaj.org/article/347125df8d3741a0bcbe5c96db205614
Autor:
Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, Andrii Domanskyi, Riikka H. Hämäläinen, Gundars Goldsteins, Jari Koistinaho, Tarja Malm, Sweelin Chew, Kirsi Rilla, Anthony R. White, Nicholas Marsh-Armstrong, Katja M. Kanninen
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105753- (2022)
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is a
Externí odkaz:
https://doaj.org/article/90b3b33e12fd4d749b99c1ac7e4e3bbb
Autor:
Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M. Polo, Trevor Wilson, Mika Komppula, Teemu Rönkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R. White, Pasi Jalava, Katja M. Kanninen
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative stress and inflammatio
Externí odkaz:
https://doaj.org/article/1c2a6611524442c9936f8b5edcd03f3f