Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anthony R. Vega"'
Autor:
Vishruth Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, Anthony R. Vega, Bryan D. Ryder, Charles L. White, Marc. I. Diamond, Lukasz A. Joachimiak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The authors developed a computational approach to probe the stability of amyloid fibrils and discover networks of hotspot interactions. Understanding the mechanisms of amyloid folding will help identify novel methods to treat protein (mis)folding dis
Externí odkaz:
https://doaj.org/article/34f3c028b8a641bd82ea0612f902b308
Autor:
Anthony R. Vega, Rati Chkheidze, Vipul Jarmale, Ping Shang, Chan Foong, Marc I. Diamond, Charles L. White, Satwik Rajaram
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormalities in the cerebral cortex becaus
Externí odkaz:
https://doaj.org/article/7bfd05c8d8894bc7b7ce09560f907a9c
Autor:
Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Publikováno v:
eLife, Vol 8 (2019)
During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radiall
Externí odkaz:
https://doaj.org/article/4967687a42254a76a7c714088eb669a4
Autor:
Vishruth Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, Anthony R. Vega, Bryan D. Ryder, Charles L. White, Marc. I. Diamond, Lukasz A. Joachimiak
Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformation of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can adopt a diversity of folds and form multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2845e038c1ac152928bec3ac55666536
https://doi.org/10.1101/2022.07.01.498342
https://doi.org/10.1101/2022.07.01.498342
Autor:
Dana A. Dodd, Michael LaCroix, Clarissa Valdez, Gregory M. Knox, Anthony R. Vega, Ashwani Kumar, Chao Xing, Charles L. White, Marc I. Diamond
Neurodegenerative tauopathies, including Alzheimer’s disease and related disorders, are caused by intracellular aggregation of tau protein in ordered assemblies. Experimental evidence suggests that tau assemblies propagate pathology across brain ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8870ad9eb0e89b12532a322309efd99c
https://doi.org/10.1101/2022.05.10.491429
https://doi.org/10.1101/2022.05.10.491429
Autor:
Sourav Kolay, Anthony R. Vega, Dana A. Dodd, Valerie A. Perez, Omar M. Kashmer, Charles L. White, Marc I. Diamond
Tau assembly propagation from the extracellular to intracellular space of a cell may underlie neurodegenerative tauopathies. The first step involves tau binding to heparan sulfate proteoglycans on the cell surface, followed by macropinocytosis. Patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d197a6492d22879ad1494c98554b004
https://doi.org/10.1101/2022.01.03.474802
https://doi.org/10.1101/2022.01.03.474802
Autor:
Sourav Kolay, Anthony R. Vega, Dana A. Dodd, Valerie A. Perez, Omar M. Kashmer, Charles L. White, Marc I. Diamond
Publikováno v:
The Journal of biological chemistry. 298(6)
Tau assembly movement from the extracellular to intracellular space may underlie transcellular propagation of neurodegenerative tauopathies. This begins with tau binding to cell surface heparan sulfate proteoglycans, which triggers macropinocytosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310937b84ef3bf4eb790849c60aa300
https://pubmed.ncbi.nlm.nih.gov/35525272
https://pubmed.ncbi.nlm.nih.gov/35525272
Autor:
Marc I. Diamond, Chan Foong, Charles L. White, Anthony R. Vega, Ping Shang, Rati Chkheidze, Satwik Rajaram, Vipul Jarmale
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormalities in the cerebral cortex because the can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d77e8bec8e8a1cfb75191932ec3c1
https://pubmed.ncbi.nlm.nih.gov/34674762
https://pubmed.ncbi.nlm.nih.gov/34674762
Autor:
Sungsoo Lee, Anthony R. Vega, Tae Kim, Bruno da Rocha-Azevedo, Mark Kittisopikul, Luciana R. de Oliveira, Khuloud Jaqaman, Aparajita Dasgupta
SummaryThe nanoscale organization of cell surface receptors plays an important role in signaling. We determined this organization and its relation to receptor activation for VEGF Receptor-2 (VEGFR-2), a critical receptor tyrosine kinase in endothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ca84a8ed8101c6611394db5fd887dd
Autor:
Tomomi Tani, Ashley M. Lakoduk, Ronald D. Vale, Khuloud Jaqaman, Anthony R. Vega, Satyajit Mayor, Xiaolei Su, Jonathon A. Ditlev, Darius Vasco Köster, Michael K. Rosen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b215b1da461b29279485af74f4e9b577
https://doi.org/10.7554/elife.42695.061
https://doi.org/10.7554/elife.42695.061