Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anthony R. Prosser"'
Autor:
Vincent C. Bond, Anthony R. Prosser, Ming-Bo Huang, Valarie M. Truax, Dennis C. Liotta, Kyle E. Giesler, Brooke M Katzman, Lawrence J. Wilson
Publikováno v:
Oncotarget
The chemokine receptor CXCR4 plays an integral role in the development of highly metastatic breast cancer and in the pathogenesis of chronic HIV infection. In this study, we compared the effects of CXCR4 antagonists on apoptosis induction in hematopo
Autor:
Yong Zhang, Madeleine Héroux, Bryan Cox, Brooke M Katzman, Brigitte Murat, Lawrence J. Wilson, Anthony R. Prosser, Ana A. Alcaraz, Dennis C. Liotta, Andrew J. Tebben, Gretchen M. Schroeder, James P. Snyder
[Image: see text] The rationale for the structural and mechanistic basis of a tetrahydroisoquinoline (THIQ) based series of CXCR4 antagonists is presented. Using the previously reported crystal structures which reveal two distinct binding sites of CX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed94921ea08225465c7be2c6bdcf6758
https://europepmc.org/articles/PMC6331156/
https://europepmc.org/articles/PMC6331156/
Autor:
Bryan Cox, Sangil Lee, Yongnian Sun, Ming B. Huang, Vincent C. Bond, Anthony R. Prosser, Zhufang Li, Lawrence J. Wilson, Mark Krystal, James P. Snyder, Dennis C. Liotta
Publikováno v:
ACS Medicinal Chemistry Letters. 6:753-757
We report novel anti-HIV-1 agents with combined dual host-pathogen pharmacology. Lead compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent mechanisms of action: (1) non-nucleoside reverse transcriptase inhibition, (2) CCR5-me
Publikováno v:
Expert Opinion on Therapeutic Patents. 24:1349-1366
The NMDA receptor mediates a slow component of excitatory synaptic transmission, and NMDA receptor dysfunction has been implicated in numerous neurological disorders. Thus, interest in developing modulators that are capable of regulating the channel
Autor:
Anthony R. Prosser, Dennis C. Liotta
Publikováno v:
Tetrahedron Letters. 56:3005-3007
A convenient, single-pot protocol for the transformation of esters into analytically pure ketones is described herein. This method circumvents the need for purification and affords near quantitative yields for all substrates investigated. As a test o
Publikováno v:
Organic Letters. 12:3968-3971
A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane car
Publikováno v:
Organic Letters. 12:1488-1491
A new, general, and chemoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides is described. A wide range of alcohols and phenols can be employed as pronucleophiles in this transformation, providing expeditious
Autor:
Dennis C. Liotta, Anthony R. Prosser
Publikováno v:
ChemInform. 46
The robust and scalable title method is based on the reaction between methyl 1-benzylpiperidine-4-carboxylate and primary Grignard reagents, but fails using secondary Grignard reagents.
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
A novel series of CXCR4 antagonists with substituted piperazines as benzimidazole replacements is described. These compounds showed micromolar to nanomolar potency in CXCR4-mediated functional and HIV assays, namely inhibition of X4 HIV-1(IIIB) virus
Autor:
Anthony R. Prosser, Brooke M Katzman, James P. Snyder, Lawrence J. Wilson, Ana A. Alcaraz, Dennis C. Liotta, Bryan Cox
The CXC chemokine receptor 4 (CXCR4) is involved in chemotaxis and serves as a coreceptor for T-tropic HIV-1 viral entry, thus making this receptor an attractive drug target. Recently, crystal structures of CXCR4 were reported as complexes with the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4286a3a171faeaf30f441a4adaeeca0
https://europepmc.org/articles/PMC5776682/
https://europepmc.org/articles/PMC5776682/