Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anthony R Dallosso"'
Autor:
Anthony R Dallosso, Anne L Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W Brown, Karim Malik
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000745 (2009)
Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We there
Externí odkaz:
https://doaj.org/article/7af8fa26a11e4c70987e9295678bdc7f
Autor:
Jeremy P. Cheadle, Thomas Scholl, Richard Wenstrup, Julian R. Sampson, Cynthia Frye, Valentina Moskvina, James Colley, Edward Rawstorne, Natalie Jones, Brant C. Hendrickson, Kristilyn Eliason, Anthony R. Dallosso, Duncan Azzopardi
Supplementary Tables S1 & S2 from Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2faa7989d9549c33ee98d6950d46357
https://doi.org/10.1158/0008-5472.22374266
https://doi.org/10.1158/0008-5472.22374266
Autor:
Jeremy P. Cheadle, Thomas Scholl, Richard Wenstrup, Julian R. Sampson, Cynthia Frye, Valentina Moskvina, James Colley, Edward Rawstorne, Natalie Jones, Brant C. Hendrickson, Kristilyn Eliason, Anthony R. Dallosso, Duncan Azzopardi
It has been proposed that multiple rare variants in numerous genes collectively account for a substantial proportion of multifactorial inherited predisposition to a variety of diseases, including colorectal adenomas (CRA). We have studied this hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ea15f7a9b874c8170615e5fc6b2bbd
https://doi.org/10.1158/0008-5472.c.6497375
https://doi.org/10.1158/0008-5472.c.6497375
Autor:
Abdulrahman Almesned, Dorien Schepers, Mehran Beiraghi Toosi, Zuhair N. Al-Hassnan, Jill A. Rosenfeld, Erin M. Miller, Hassan Mottaghi Moghaddam Shahri, Maaike Alaerts, Melanie Perik, Desiderio Rodrigues, Aline Verstraeten, Reza Maroofian, Silke Peeters, Cédric H. G. Neutel, Ilse Luyckx, Nicole Revencu, Jenny C. Taylor, Jarl Bastianen, Isabel Pintelon, Henry Houlden, Matteo P. Ferla, Erik Fransen, Kayal Vijayakumar, Lut Van Laer, Anthony R. Dallosso, Mandy Vermont, Isabelle Maystadt, Lotte Van Den Heuvel, Thierry Sluysmans, David Murphy, K. Nicole Weaver, Paria Najarzadeh Torbati, Jotte Rodrigues Bento, Amber Begtrup, Maggie Williams, Ilse Van Gucht, Maaike Bastiaansen, Ashish Chikermane, Gangadhara Bharmappanavara, Alistair T. Pagnamenta, Bart Loeys, Joe Davis Velchev, Julie Evans, Josephina A.N. Meester, Narges Hashemi, Julie Vogt, Pieter-Jan Guns
Publikováno v:
The American Journal of Human Genetics
American Journal of Human Genetics, 108, 1115-1125
American Journal of Human Genetics, 108, 6, pp. 1115-1125
Am J Hum Genet
The American journal of human genetics
American Journal of Human Genetics, 108, 1115-1125
American Journal of Human Genetics, 108, 6, pp. 1115-1125
Am J Hum Genet
The American journal of human genetics
Importin 8, encoded by IPO8, is a ubiquitously expressed member of the importin-beta protein family that translocates cargo molecules such as proteins, RNAs, and ribonucleoprotein complexes into the nucleus in a RanGTP-dependent manner. Current knowl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24e6c0679dae811ef67aedbd6e7ffa5
https://doi.org/10.1016/j.ajhg.2021.04.019
https://doi.org/10.1016/j.ajhg.2021.04.019
Autor:
Anthony R. Dallosso, Zsombor Melegh, Madhu Kollareddy, Jacob Bellamy, Marianna Szemes, Karim Malik, Daniel Catchpoole
Publikováno v:
Bellamy, J, Szemes, M, Melegh, Z, Dallosso, A, Kollareddy, M, Catchpoole, D & Malik, K 2020, ' Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma ', Frontiers in Oncology, vol. 10, 818 . https://doi.org/10.3389/fonc.2020.00818
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Targeted inhibition of proteins modulating epigenetic changes is an increasingly important priority in cancer therapeutics, and many small molecule inhibitors are currently being developed. In the case of neuroblastoma (NB), a paediatric solid tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a3e74c1d6d7d11b92eabedb9b32d87
https://hdl.handle.net/1983/ac563702-3a6a-4664-b509-0c7646a9da48
https://hdl.handle.net/1983/ac563702-3a6a-4664-b509-0c7646a9da48
Autor:
Jessica Charlet, Keith W. Brown, Karim Malik, Bader Almutairi, Heather C. Etchevers, Anthony R. Dallosso, Marianna Szemes
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, pp.18934. ⟨10.1038/s41598-019-55382-6⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Almutairi, B, Charlet, J, Dallosso, A R, Szemes, M, Etchevers, H C, Malik, K T A & Brown, K W 2019, ' Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes ', Scientific Reports, vol. 9, 18934 (2019) . https://doi.org/10.1038/s41598-019-55382-6
Scientific Reports, Nature Publishing Group, 2019, pp.18934. ⟨10.1038/s41598-019-55382-6⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Almutairi, B, Charlet, J, Dallosso, A R, Szemes, M, Etchevers, H C, Malik, K T A & Brown, K W 2019, ' Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes ', Scientific Reports, vol. 9, 18934 (2019) . https://doi.org/10.1038/s41598-019-55382-6
International audience; To discover epigenetic changes that may underly neuroblastoma pathogenesis, we identified differentially methylated genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neuroblastom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a067218f3e90574140fe1ebd29da0
https://doi.org/10.1038/s41598-019-55382-6
https://doi.org/10.1038/s41598-019-55382-6
Autor:
Jessica, Charlet, Ayumi, Tomari, Anthony R, Dallosso, Marianna, Szemes, Martina, Kaselova, Thomas J, Curry, Bader, Almutairi, Heather C, Etchevers, Carmel, McConville, Karim T A, Malik, Keith W, Brown
Publikováno v:
Molecular Carcinogenesis
Neuroblastoma is a childhood cancer in which many children still have poor outcomes, emphasising the need to better understand its pathogenesis. Despite recent genome‐wide mutation analyses, many primary neuroblastomas do not contain recognizable d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16199656aa535341e58d90193c9382b5
https://pubmed.ncbi.nlm.nih.gov/27862318
https://pubmed.ncbi.nlm.nih.gov/27862318
Autor:
Adrian Charles, Gillian F.J. White, Anthony R. Dallosso, Jessica Charlet, Karim Malik, Keith W. Brown, Graham R. Standen
Publikováno v:
Cancer Genetics. 205:319-326
Despite considerable advances in understanding the molecular pathogenesis of Wilms' tumor (WT), its cell biology is less well understood, partly due to the paucity of established WT cell lines. We report here the establishment of a new anaplastic WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f106453e9a80f921367bd06babf047a8
https://doi.org/10.1016/j.cancergen.2012.04.009
https://doi.org/10.1016/j.cancergen.2012.04.009
Autor:
Anthony R. Dallosso, C Owen, Thomas J. Curry, Anne L. Hancock, Kasper Thorsen, Alexander Greenhough, Claus L. Andersen, Karim Malik, Bodil Øster, Christos Paraskeva, M Frank, Marianna Szemes
Publikováno v:
Dallosso, A R, Øster, B, Greenhough, A, Thorsen, K, Curry, T J, Owen, C, Hancock, A L, Szemes, M, Paraskeva, C, Frank, M, Andersen, C L & Malik, K 2012, ' Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways ', Oncogene, no. 31, pp. 4409-4419 . https://doi.org/10.1038/onc.2011.609
Loss of tumour suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES), and genome-wide analyses have revealed that LRES is present in many cancer type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad58dc41622b944e03c13e76f97fdc04
https://doi.org/10.1038/onc.2011.609
https://doi.org/10.1038/onc.2011.609
Autor:
Siân Jones, Geraint T. Williams, Peter Milewski, Valentina Moskvina, Jeremy Peter Cheadle, Nada Al-Tassan, Shelley Idziaszczyk, Sally Williams, Julian R. Sampson, John Beynon, Duncan Azzopardi, D. Rhodri Davies, Anthony R. Dallosso
Publikováno v:
Human Mutation. 30:1412-1418
Multiple rare nonsynonymous variants in APC predispose to colorectal adenomas. The mechanisms through which such variants act have been unclear, but it has been proposed that a specific ("just-right") level of beta-catenin signaling is required for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd23e77d69ed722fc2c737b30c444136
https://doi.org/10.1002/humu.21089
https://doi.org/10.1002/humu.21089