Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Anthony R, Harris"'
Autor:
Dominik K. Kölmel, Jinqiao Wan, Barry A. Morgan, Hongyao Zhu, Mark Edward Flanagan, Sylvie K. Sakata, Anthony R. Harris
Publikováno v:
The Chemical Record. 21:616-630
This Personal Account describes the authors' foray into DNA-encoded libraries. The article addresses several key aspects of this hit generation technology, from the development of new synthetic methodology to the subsequent conception, design, and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10728fc7eb0789d60bc42ea8e82521f4
https://doi.org/10.1002/tcr.202000148
https://doi.org/10.1002/tcr.202000148
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b93599ae79500f98919ddfa6e48aa
https://doi.org/10.1021/acsmedchemlett.0c00029
https://doi.org/10.1021/acsmedchemlett.0c00029
Autor:
Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
Publikováno v:
Journal of Medicinal Chemistry. 60:6649-6663
Recent data demonstrated that activation of the muscarinic M1 receptor by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI) and cardiovascular (CV) cholinergic adverse events (AEs) previously attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
https://doi.org/10.1021/acs.jmedchem.7b00597
https://doi.org/10.1021/acs.jmedchem.7b00597
Autor:
Kayla Burrell, Audrey Player, Lisa Nunez, Iria Ondo Bengone, Anthony R. Harris, Sharon Kwende, Nissi Abraham, Wiley Walls, Telisa Willaims
Publikováno v:
Genes & Cancer
When triple negative breast cancer (TNBC) are analyzed by gene expression profiling different subclasses are identified, at least one characterized by genes related to immune signaling mechanisms supporting the role of these genes in the cancers. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f34a6c00c9a9acd6cf75133d323831b
http://europepmc.org/articles/PMC5620011
http://europepmc.org/articles/PMC5620011
Autor:
Peter Harris, Anthony R. Harris
Publikováno v:
Journal of Business & Economics Research (JBER). 15:1-4
Until very recently, the Last In First Out method (LIFO) was under severe scrutiny from the financial community, and its repeal as an acceptable accounting method seemed imminent. There were pressures from the Securities and Exchange Commission and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6533a962ac6b2018bdd6ec1f2aa6a8e8
https://doi.org/10.19030/jber.v15i1.9852
https://doi.org/10.19030/jber.v15i1.9852
Autor:
Anthony R. Harris, Barry A. Morgan, Jinqiao Wan, Mark Edward Flanagan, Sylvie K. Sakata, Dominik K. Kölmel, Hongyao Zhu
Publikováno v:
The Chemical Record. 21:615-615
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423db3ee1f1736f105c142060f52c457
https://doi.org/10.1002/tcr.202180401
https://doi.org/10.1002/tcr.202180401
Autor:
Jotham Wadsworth Coe, Brajesh K. Rai, Sidney Liang, Keith Dlugolenski, Jennifer E. Davoren, Erik Alphie Lachapelle, Rebecca E. O’Connor, Deane M. Nason, Christine C. Orozco, David Gray, Rouba Kozak, Christopher John Helal, Brian Samas, Yue Liu, Michelle A. Salafia, Anthony R. Harris, Wenjian Xu
Publikováno v:
Journal of medicinal chemistry. 61(24)
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known D1-selective agonists are catecholamines that bring about receptor desensitization and undergo rapid m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b084e9e7a5c6d066edd7c22acfa061cd
https://pubmed.ncbi.nlm.nih.gov/30431269
https://pubmed.ncbi.nlm.nih.gov/30431269
Autor:
Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
Publikováno v:
Journal of medicinal chemistry. 61(7)
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report the discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba4448563e7b467bb25a055a46ddd6
https://pubmed.ncbi.nlm.nih.gov/29498843
https://pubmed.ncbi.nlm.nih.gov/29498843
Autor:
Christopher W. am Ende, Tracy Brown Phillips, Bruce N. Rogers, Stephen Noell, Michael Aaron Brodney, Zhen Huang, Laura A. McAllister, Kimberly F. Fennell, Shuangyi Wan, Douglas S. Johnson, Anthony R. Harris, John D. Knafels, Jane Wang, Tarek A. Samad, Jayvardhan Pandit, Scot Richard Mente, Timothy L. Foley, Justin R. Piro, Christopher Ryan Butler, Steven J. Hawrylik, Elizabeth Mary Beck, Kari R. Fonseca
Publikováno v:
Journal of medicinal chemistry. 60(23)
Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor to the proinflammatory eicosann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbbf3b680c7625f463d2994b5c544c1
https://pubmed.ncbi.nlm.nih.gov/29148769
https://pubmed.ncbi.nlm.nih.gov/29148769
Autor:
Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
Publikováno v:
Journal of medicinal chemistry. 60(15)
Recent data demonstrated that activation of the muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29248df43dd90a74489fbab479a9cfba
https://pubmed.ncbi.nlm.nih.gov/28598634
https://pubmed.ncbi.nlm.nih.gov/28598634