Výsledky vyhledávání - "Anthony Prandina"

Akademický článek

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Autor: Samar Issa, Anthony Prandina, Nicolas Bedel, Pål Rongved, Saïd Yous, Marc Le Borgne, Zouhair Bouaziz

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1321-1346 (2019)

For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products. Carbazoles have taken an important part in all the existing anti-cancer drugs because of

Externí odkaz: https://doaj.org/article/b6722b80ea7e4f35b7f6658a192d0578

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Akademický článek

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles

Autor: Anthony Prandina, Lars Herfindal, Sylvie Radix, Pål Rongved, Stein O. Døskeland, Marc Le Borgne, Florent Perret

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 370-375 (2018)

Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. Its water solubility has le

Externí odkaz: https://doaj.org/article/f8efd2d694984d28a404868dc1bc4ce7

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Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Autor: Saïd Yous, Pal Rongved, Samar Issa, Marc Le Borgne, Nicolas Bedel, Zouhair Bouaziz, Anthony Prandina

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1321-1346. ⟨10.1080/14756366.2019.1640692⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1321-1346 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.1321-1346. ⟨10.1080/14756366.2019.1640692⟩

International audience; For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products. Carbazoles have taken an important part in all the existing anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfd9cb87fbb61e794dc4fdea723107a
http://europepmc.org/articles/PMC6691762

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Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

Autor: Sylvie Radix, Adriana Magalhaes Santos Andresen, Christopher Fröhlich, Christian Schnaars, Ole Andreas Økstad, Ørjan Samuelsen, Silje Lauksund, Anthony Prandina, Ove Alexander Høgmoen Åstrand, Adam Heikal, Roya Popal, Lars Petter Jordheim, Marc Le Borgne, Geir Kildahl-Andersen, Tor Gjøen, Pal Rongved

Publikováno v: ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2018, ⟨10.1021/acsinfecdis.8b00137⟩

The rise of antimicrobial resistance (AMR) worldwide and the increasing spread of multi-drug-resistant organisms expressing metallo-β-lactamases (MBL) require the development of efficient and clinically available MBL inhibitors. At present, no such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a99720e5a1149d53c0d780d8118c69
https://doi.org/10.1021/acsinfecdis.8b00137

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Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

Autor: Pal Rongved, Marc Le Borgne, Lars Petter Jordheim, Christopher Fröhlich, Sylvie Radix, Ove Alexander Høgmoen Åstrand, Anthony Prandina, Tor Gjøen, Silje Lauksund, Christian Schnaars, Ørjan Samuelsen, Adriana Magalhaes Santos Andresen, Geir Kildahl-Andersen

Publikováno v: MedChemComm
MedChemComm, Royal Society of Chemistry, In press, 10 (4), pp.528-537. ⟨10.1039/C8MD00578H⟩

International audience; The syntheses of metallo-β-lactamase inhibitors comprising chelating moieties, with varying zinc affinities,and peptides partly inspired from bacterial peptide sequences, have been undertaken. The zinc chelatorstrength was va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeeeb423d35ab7e14d9a5a80a9ccf4e
https://hal.archives-ouvertes.fr/hal-02077900

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Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors

Autor: Zineb Bousfiha, Espen Frøvold, Lars Petter Jordheim, Christopher Fröhlich, Anthony Prandina, Sylvie Radix, Ørjan Samuelsen, Ove Alexander Høgmoen Åstrand, Marc Le Borgne, Pal Rongved, Hanna-Kirsti S. Leiros

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2019, 75 (11), pp.1525-1540. ⟨10.1016/j.tet.2019.02.004⟩

Antibiotics are key drugs in modern healthcare, especially in hospitals, where multiresistant bacteria resides and is a potential threat to human health. In the present work, a new series of adjuvants working synergistically with the carbapenem merop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e1b96f2ca9fcecb4e761c2469d38ab
https://hdl.handle.net/10037/17889

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Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles

Autor: Pal Rongved, Stein Ove Døskeland, Anthony Prandina, Sylvie Radix, Lars Herfindal, Marc Le Borgne, Florent Perret

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of enzyme inhibition and medicinal chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2018, 33 (1), pp.370-375. ⟨10.1080/14756366.2017.1421638⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 370-375 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd701043bc7e12afcd24d03dc016aed
https://pubmed.ncbi.nlm.nih.gov/29336193

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Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives

Autor: Simen Snellingen, Ove Alexander Høgmoen Åstrand, Tore Bonge-Hansen, Stein Ove Døskeland, Pal Rongved, Reidun Aesoy, Lars Herfindal, Misbah Sabir, Elvar Örn Viktorsson, Bendik Melling Grøthe, Anthony Prandina

Publikováno v: Bioorganicmedicinal chemistry. 25(7)

A new efficient total synthesis of the phenazine 5,10-dioxide natural products iodinin and myxin and new compounds derived from them was achieved in few steps, a key-step being 1,6-dihydroxyphenazine di-N-oxidation. Analogues prepared from iodinin, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19dbffeadbf4faf10c58fe369c70fc7
https://pubmed.ncbi.nlm.nih.gov/28284865

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