Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anthony Pennello"'
Autor:
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N. Haidar, Dale L. Ludwig, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable
Externí odkaz:
https://doaj.org/article/23eb068b1c80433fb11267b151e41edf
Autor:
Inga J. Duignan, Erik Corcoran, Anthony Pennello, Mary Jane Plym, Michael Amatulli, Nidia Claros, Michelle Iacolina, Hagop Youssoufian, Larry Witte, Selda Samakoglu, Jonathan Schwartz, David Surguladze, James R. Tonra
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 1, Pp 49-59 (2011)
The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non–endothelial stromal cells to further impact tumor cell growth and su
Externí odkaz:
https://doaj.org/article/4d7f4f7b9cc14e00ab7edc9c7481333c
Autor:
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N. Haidar, Dale L. Ludwig, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-1 (2018)
Unfortunately, after publication of this article [1], it was noticed that corrections to the legends of Figs. 1 and 2 were not correctly incorporated. The correct legends can be seen below.
Externí odkaz:
https://doaj.org/article/fdf1b617c54c4afb9fbc0522a222a977
Autor:
Douglas Burtrum, Helen Kotanides, Leyi Shen, Darin Chin, Ruslan D. Novosiadly, Amelie Forest, Rose Marie Sattler, Xinlei Chen, Yiwei Zhang, Michael Topper, David Surguladze, Jingxing Li, Jaafar N. Haidar, Ivan Inigo, Gregory D. Plowman, Colleen A. Burns, Lauren Boucher, Andreas Sonyi, Prachi Sharma, Michael Kalos, Dale L. Ludwig, Maria B. Lebron, Anthony Pennello, Carmine Carpenito, Juqun Shen
Publikováno v:
Molecular Cancer Therapeutics. 19:988-998
The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in combination with other
Autor:
Bing Han, Yiwen Li, Carmine Carpenito, Andreas Sonyi, Jaafar N. Haidar, Anthony Pennello, Scott W. Eastman, Michael Kalos, Xinlei Chen, Gregory D. Plowman, Ruslan D. Novosiadly, Sagit Hindi, Timothy Bailey, Christopher M. Moxham, Krishnadatt Persaud, Dale L. Ludwig, Yiwei Zhang, Yanbin Lao, George Wang, Darin Chin, Helen Kotanides, David Surguladze, Yang Shen, Danielle Kathryn Bulaon, Stacy Torgerson, Maria Malabunga, Ivan Inigo, Michael Topper
Publikováno v:
Cancer immunology research. 8(10)
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell–mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide
Autor:
Andreas Sonyi, Michael Kalos, Anthony Pennello, Douglas Burtrum, Mary Murphy, Xinlei Chen, George Wang, David Surguladze, Ivan Inigo, Yiwei Zhang, Jaafar N. Haidar, Carmine Carpenito, Maria Malabunga, Darin Chin, Amelie Forest, Ruslan D. Novosiadly, Gerald Hall, Dale L. Ludwig, Leyi Shen, Yiwen Li, Laurent Malherbe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Background Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective
Autor:
Douglas Burtrum, Laurent Malherbe, David Surguladze, Dale L. Ludwig, Ruslan D. Novosiadly, Anthony Pennello, George Wang, Xinlei Chen, Yiwen Li, Gerald Hall, Mary Murphy, Ivan Inigo, Maria Malabunga, Leyi Shen, Darin Chin, Carmine Carpenito, Amelie Forest, Yiwei Zhang, Andreas Sonyi, Michael Kalos, Jaafar N. Haidar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-1 (2018)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective
Autor:
Anthony Pennello, Dale L. Ludwig, Xiaodi Ren, David Surguladze, Gregory D. Plowman, Scott W. Eastman, Elizabeth Navarro, Yung-mae Yao, Alan C. Rigby, Chris Moxham, Paul Balderes, Nelusha Amaladas, Tim Mack, Michael Topper
Publikováno v:
Cancer Research. 79:4835-4835
Fibroblast growth factor receptor 3 (FGFR3) has been shown to be constitutively activated in bladder, multiple myeloma, non-small cell lung cancer (NSCLC), glioblastoma multiforme, and cervical cancer through overexpression, point mutations, and tran
Autor:
Dipa Patel, Qinwei Zhou, Aiping Zhu, Kris Persaud, Tim Blanc, Marshall Snavely, Dale L. Ludwig, Paul Balderes, Anthony Pennello, Yang Shen, David Surguladze, Yun Kenneth Kang, Stanley Ng, Lin Zeng, Sagit Hindi, Amtul Bari
Publikováno v:
mAbs
Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 l
Autor:
Gerald Hall, Darin Chin, Amelie Forest, Dale L. Ludwig, Ruslan D. Novosiadly, Kris Persaud, George Wang, Maria Malabunga, Andreas Sonyi, Michael Kalos, Leyi Shen, Mary Murphy, Cindy Wang, Ivan Inigo, Yung-mae Yao, Douglas Burtrum, Anthony Pennello, David Surguladze, Carmine Carpenito, Jaafar N. Haidar, Yiwen Li
Publikováno v:
Cancer Research. 78:2730-2730
Modulating the PD-L1/PD-1 axis in man through function blocking antibodies can release potent anti-tumor immunity, leading to durable objective responses across multiple tumor types. Here we describe the discovery and preclinical characterization of